HemOnc Today


The following articles appeared in the print edition of HEMONC TODAY.

Table of Contents
Cover Story

FDA guidance highlights inappropriate use of power morcellation, but concern about interpretation lingers


ASCO statement on Medicaid reform reflects physicians’ professional responsibilities

Derek Raghavan, MD, PhD

FDA approvals

FDA grants orphan drug status to ovarian cancer treatment

FDA grants fast track status to SGX301 for cutaneous T-cell lymphoma

FDA News

FDA grants fast track designation to CPX-351 for AML

In the Journals

Subcutaneous, IV trastuzumab similarly safe, effective for HER-2-positive early breast cancer

Shorter therapy did not compromise outcomes in low-risk embryonal rhabdomyosarcoma

Subset of patients less likely to develop subsequent keratinocyte carcinoma

Addition of head, neck exam to lung cancer screening may increase early detection of HNSCC

Olaparib plus chemotherapy extended PFS in recurrent platinum-sensitive ovarian cancer

PD-L1 expression, CD8+ T-cell counts associated with shorter OS in mRCC

PET/CT may be new standard for response assessment in follicular lymphoma

Oral HPV16 infection persisted longer in older men

Palbociclib plus letrozole doubled PFS in advanced HER-2-negative breast cancer

Proton therapy, IMRT demonstrated similar toxicity profiles in prostate cancer

Rate of US medical research investment drops

Philadelphia chromosome-like ALL demonstrates alterations potentially targetable by TKIs

Prognostic POLE proofreading may reduce overtreatment of endometrial cancer

Malignant bowel obstruction palliative surgery linked to complications, mortality

ASCT regimen shows promise for CNS-involved non-Hodgkin’s lymphoma

Observation most common adjuvant management for stage I testicular seminoma

p16 expression predicted outcomes in non-OPSCC

Age-related clonal hematopoiesis increased risk for hematologic malignancies

Primary melanoma regression not linked to sentinel node status

Second-line SBRT plus erlotinib extended survival in advanced NSCLC

Time to diagnosis not associated with survival in adolescents with Ewing tumors

Vigilant surveillance for esophageal carcinoma relapse appropriate after bimodality therapy

Weekly prophylaxis with nonacog beta pegol safe, effective for hemophilia B

Thyroid cancer conditional survival affected by age, cancer stage, survivorship phase

Tumor size, location, grade predicted late recurrence in soft tissue sarcoma

IMRT reduced recurrence rates in primary soft tissue sarcoma

Lenalidomide plus rituximab induced high response rate in untreated indolent lymphoma

Carboplatin–paclitaxel combination shows promise for rare form of thymus cancer

Aprepitant regimen reduced CINV in post-transplant myeloma

Normal D-dimer levels after anticoagulant therapy may indicate lower recurrence of VTE

Early palliative care improved quality of life in patients with advanced-stage cancers

Crizotinib superior to chemotherapy in advanced, ALK-positive NSCLC

Complete mesocolic excision for colon cancer yielded better DFS than conventional surgery

Early referral to outpatient palliative care improved end-of-life care

High vitamin D levels associated with lower CRC risk, increased immune response

GTX effective neoadjuvant treatment in locally advanced pancreatic cancer

Exercise improved aromatase inhibitor-induced arthralgia in breast cancer survivors

Children who remain leukemia-free 5 years after diagnosis considered cured

Active surveillance for small papillary thyroid cancers should be used with caution

AACR, ASCO recommend regulation of e-cigarettes, other electronic nicotine delivery systems

Women with breast cancer demonstrate elevated long-term risk for depression

Adjuvant chemoradiotherapy may improve survival in head and neck Merkel cell carcinoma

BRCA testing has 'clear role' for triple-negative breast cancer

Bisphosphonate treatment did not reduce risk for postmenopausal breast cancer

Ado-trastuzumab emtansine significantly extended OS in HER-2–positive breast cancer with CNS metastases

Keratinization may be prognostic in certain head and neck cancers

Ipilimumab plus fotemustine demonstrated long-term efficacy in metastatic melanoma

Nivolumab superior to dacarbazine for untreated metastatic melanoma

Most blood clot treatments demonstrate similar efficacy, safety

More studies urged in managing posttreatment fatigue in thyroid cancer

IG-IMRT showed favorable outcomes in skull base chordoma, chondrosarcoma

HPV testing recommended as primary screening option for cervical cancer

Higher coffee consumption shows ties to decreased melanoma risk

Institution Notes

Medical Center appoints director of thoracic oncology immunotherapeutics

Cancer center names new deputy director

Kimmel Cancer Center appoints director of thoracic oncology

Einstein, Montefiore appoint chair of gynecology

Physicians named to NCI task forces

Roswell Park Cancer Institute names chief of clinical services

Meeting News Coverage

Some patients with rectal cancer may safely avoid surgery

Panitumumab plus FOLFOX6 benefited patients with RAS wild-type metastatic colorectal cancer

Lanreotide shows promise in patients with pancreatic neuroendocrine tumors

Less-intensive regimen maintained efficacy, reduced toxicity in metastatic pancreatic cancer

Practice Management

ASCO: CancerLinQ to provide 'big data' to improve patient care