HemOnc Today


The following articles appeared in the print edition of HEMONC TODAY.

Table of Contents

Personalized T-cell therapy yields promising outcomes in relapsed, refractory CLL

Cover Story

VTE risk in patients with cancer often overlooked understudied

Drug Pipeline

Hematology Drugs in the Pipeline


Peto's paradox: Elephants, whales, Chihuahuas and cancer

Derek Raghavan, MD, PhD

FDA approvals

FDA approves ultrasound system for targeted prostate treatment

FDA approves Onivyde as part of combination regimen for treatment of metastatic pancreatic cancer

FDA approves Praxbind for Pradaxa reversal

FDA approves Coagadex for hereditary Factor X deficiency

FDA News

FDA approves Yondelis for treatment of specific unresectable or metastatic soft tissue sarcomas

FDA grants orphan drug designation to STM 434 for ovarian cancer

FDA grants breakthrough therapy designation to inotuzumab ozogamicin for ALL

FDA grants avelumab fast track designation for metastatic Merkel cell carcinoma

In the Journals

Kallikrein markers improve high-grade prostate cancer detection, reduce unnecessary biopsies

Idarucizumab rapidly reverses anticoagulant effect of dabigatran, restores hemostasis

Including arsenic trioxide in induction, consolidation therapy shows promise for APL

IVC filter retrieval rate high with minimal complications

Hospital protocol improves care for children with sickle cell disease

ACS updates breast cancer screening guideline for average-risk women

HSCT improves survival for older patients with multiple myeloma

Health insurance coverage varies by patient demographics, cancer type

Long-term survival for patients with ovarian cancer higher than expected

T-cell therapy leads to complete response in patient with refractory multiple myeloma

Triplet combination increases MRD negativity in multiple myeloma

Racial, insurance disparities influence chemotherapy receipt for colon cancer

Review examines presentation, course of major bleeding events during anticoagulation therapy

Vismodegib appears effective in medulloblastoma subtype

Vitamin K antagonists do not affect bone mineral density, fracture risk

Tumor mutations, survival in stage 3 colon cancer differ by race

Vertebral fractures common among children with ALL

Molecular prognostic index may predict survival in early-stage NSCLC

Morbidity increases among childhood cancer survivors

Many women with early-stage breast cancer receive imaging, despite practice guidelines

Mohs micrographic surgery delays not tied to nonmelanoma skin cancer tumor growth

Persistent mutations may predict EFS, OS outcomes in AML

Positive post-radiation biopsy may predict worse outcomes for early-stage prostate cancer

One alcoholic drink daily may increase risk for cancer in women

Past breast-feeding may decrease risk for breast cancer recurrence, death

Gastrointestinal stromal tumors increase risk for additional malignancies

Anticoagulation appears safe, effective in patients with splanchnic vein thrombosis

Colorectal cancer in adolescents, young adults more likely to have had heredity predisposition

Cancer remains the leading cause of death among US Hispanics

Chemotherapy plus bevacizumab extends survival in epithelial ovarian cancer

Chemotherapy plus ponatinib may improve Ph+ALL outcomes

Bevacizumab improves pathological complete response in HER-2–negative early breast cancer

HIV-associated Hodgkin’s lymphoma patients benefit from cART, ABVD

Azacitidine improves survival for older patients with AML

Circulating tumor cells predict decreased survival in cholangiocarcinoma

Financial penalties for hospital-acquired VTE do not account for unpreventable incidents

Allogeneic HSCT recipients face increased risk for skin cancer

Institution Notes

Association of American Cancer Institutes presents award

ASH presents honors awards to 28 medical students, residents

Beth Israel Deaconess Medical Center names cancer center director

NYU Langone appoints chair of radiation oncology

Association of Pediatric Hematology/Oncology Nurses presents awards

ASTRO presents Annual Meeting Nurses Abstract Award

American Society of Preventive Oncology names next president

American College of Gastroenterology elects new president

Medical College of Wisconsin appoints senior associate dean

Fox Chase researcher earns American Cancer Society honor

Meeting News Coverage

Aggressive multimodal therapy may improve outcomes for anaplastic thyroid cancer

Surgical treatment improves OS in advanced throat cancers

Thyroglobulin level, prior therapy do not predict pazopanib response in differentiated thyroid cancer

Answer to common clinical question may predict risk for death

PD-L1 expression influences DFS, therapy response in papillary thyroid cancer

IMRT for locally advanced NSCLC reduces risk for severe pneumonitis

Children with ependymoma experience favorable outcomes with immediate postoperative radiation

Metastatic lymph node size, extension predict PTC recurrence risk

Daily aspirin increases chance of gastrointestinal cancer survival

Adjuvant APBI with multicatheter brachytherapy effective for early-stage breast cancer

Follow-up by advance practice nurses improves care for patients with head, neck cancer

Despite guideline revisions, total thyroidectomy often still needed in well-differentiated thyroid cancer

Molecular differences found between tumors of younger, older CRC patients

Nivolumab, ipilimumab combination improves PFS in advanced melanoma regardless of prognostic factors

Nivolumab ‘likely to change the treatment’ of advanced renal cell carcinoma

Papillary thyroid cancer outcomes have significantly improved over time

Molecular markers predict metastases, therapy response in medullary thyroid cancer

Cabozantinib significantly prolongs OS in patients with RET-mutated medullary thyroid cancer

Cabozantinib safe, effective in advanced, refractory differentiated thyroid cancer