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Lack of transfusion capabilities linked to underuse of hospice for blood cancers

Odejide OO, et al. Cancer. 2017;doi:10.1002/cncr.30735.
Hematologic oncologists appeared to value hospice but may be concerned about the adequacy of services like transfusion for patients with blood…
In the Journals Plus

Younger age linked to poorer survival from second cancers

Keegan THM, et al. JAMA Oncol. 2017;doi:10.1001/jamaoncol.2017.0465.
Younger age at the time of a second primary malignant neoplasm diagnosis appeared linked to worse survival outcomes among cancer survivors, according…
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Perioperative interruption of direct oral anticoagulants safe, effective

Shaw J, et al. J Thromb Haemost. 2017;doi:10.1111/jth.13670.
Direct oral anticoagulant interruption before a procedure or surgery using a strategy that considered half-life and procedural bleeding risk appeared…
In the Journals Plus

Rare cancers represent 20% of US cancer diagnoses

DeSantis CE, et al. CA Cancer J Clin. 2017;doi:10.3322/caac.21400.
Rare malignancies accounted for about one in five cancer diagnoses in the United States from 2009 to 2013, according to an American Cancer Society…
In the Journals Plus

Harvoni safe, effective for HCV–infected patients with sickle cell disease

Moon J, et al. Clin Infect Dis. 2017;doi:10.1093/cid/cix441.
Harvoni, a fixed-dose combination of ledipasvir and sofosbuvir, safely and effectively treated hepatitis C virus infection in patients with sickle…
In the Journals Plus

Cancer during pregnancy associated with stillbirth, neonatal mortality

Lu D, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2016.69.9439.
Women who had cancer either during pregnancy or in the year after pregnancy faced a greater risk for neonatal mortality and stillbirth, according to
In the Journals Plus

Nivolumab shows promise for esophageal cancer

Kudo T, et al. Lancet Oncol. 2017;doi:10.1016/S1470-2045(17)30181-X.
Manfredi S and Drouillard A. Lancet Oncol. 2017;doi:10.1016/S1470-2045(17)30188-2.
Nivolumab appeared safe and effective in the treatment of patients with esophageal cancer, according to results of a phase 2 clinical trial…
In the Journals Plus

Survivors of Hodgkin lymphoma have increased risk for second cancer

Sud A, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2016.70.9709.
Survivors of Hodgkin lymphoma — particularly those with a family history of cancer — faced an increased risk for developing a second
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Axillary surgery may be avoidable for some women with breast cancer

Morrow M. JAMA Surg. 2017;doi:10.1001/jamasurg.2017.0565.
Tadros AB, et al. JAMA Surg. 2017;doi:10.1001/jamasurg.2017.0562.
Patients with triple-negative or HER-2–positive breast cancer who achieved a complete response after neoadjuvant chemotherapy appeared unlikely…
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Rivaroxaban safe, effective alternative for unprovoked VTE

Johnsen SP. Lancet Haemat. 2017;doi:10.1016/S2352-3026(17)30056-X.
Larsen TB, et al. Lancet Haemat. 2017;doi:10.1016/S2352-3026(17)30054-6.
Rivaroxaban conferred lower risk for recurrent deep vein thrombosis and pulmonary embolism than standard treatment in patients with unprovoked venous…
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Radioactive iodine therapy decreases 5-, 10-year mortality rates in differentiated thyroid carcinoma

Yang Z, et al. Thyroid. 2017;doi:10.1089/thy.2016.0650.
Treatment with radioactive iodine for differentiated thyroid carcinoma after primary surgical treatment was more effective for decreasing 5- and…
In the Journals Plus

Novel antibody-drug conjugate shows promise for advanced triple-negative breast cancer

Bardia A, et al. J Clin Oncol. 2017;doi:10.1200/JCO.2016.70.8297.
Sacituzumab govitecan — a novel antibody-drug conjugate — produced durable responses and appeared well-tolerated among pretreated
In the Journals Plus

Minimal residual disease negativity associated with longer survival in ALL

Berry DA, et al. JAMA Oncol. 2017;doi:10.1001/jamaoncol.2017.0580.
Children and adults with acute lymphoblastic leukemia who achieved
In the Journals Plus

Molecular subtyping may predict which prostate cancers benefit from androgen deprivation therapy

Zhao SG, et al. JAMA Oncol. 2017;doi:10.1001/jamaoncol.2017.0751.
The identification of prostate cancer subtypes based on luminal and basal lineage may provide a clinical tool to personalize androgen deprivation…
In the Journals Plus

Postoperative ultrasound unnecessary in papillary thyroid microcarcinoma

Baek HJ, et al. Endocr Pract. 2017;doi:10.4158/EP161723.OR.
Adults with papillary thyroid microcarcinoma who underwent hemithyroidectomy may not need follow-up postoperative ultrasound imaging at 1- or 2-year…
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Vena cava filters may have limited influence on incidence of PE

Cook AD, et al. JAMA Surg. 2017:doi:10.1001/jamasurg.2017.1018.
Kent AJ, et al. JAMA Surg. 2017;doi:10.1001/jamasurg.2017.1052.
Declining use of vena cava filter placement did not correspond with a rise in pulmonary embolism among trauma patients, according to a…
In the Journals Plus

Progressive epithelial proliferation on biopsy linked to breast cancer risk

Visscher DW, et al. J Natl Cancer Inst. 2017;doi:10.1093/jnci/djx035.
Women with benign breast biopsies that showed progressive epithelial proliferation had an increased risk for breast cancer compared with those whose…
In the Journals Plus

Patients who receive early palliative care use less health care, more support services

Adelson K, et al. J Oncol. Practice. 2017;doi:10.1200/JOP.2016.016808.
Patients hospitalized with advanced-stage cancers who received early palliative care showed decreased use of health care and increased use of
In the Journals Plus

Selumetinib fails to improve PFS in KRAS–mutant advanced NSCLC

Jänne PA, et al. JAMA. 2017;doi:10.1001/jama.2017.3438.
Kaufman J and Stinchcombe TE. JAMA. 2017;doi:10.1001/jama.2017.3436.
The addition of selumetinib to docetaxel did not improve PFS among patients with KRAS–mutant non–small cell lung cancer, according to…
In the Journals Plus

Active surveillance appropriate for PTC during pregnancy

Oh HS, et al. Thyroid. 2017;doi:10.1089/thy.2016.0618.
Women with papillary thyroid cancer during pregnancy can appropriately be treated with active surveillance and delayed thyroid surgery because there…