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Chronic fungal lesions predisposed to malignancy

March 2, 2015

Researchers in Brazil documented seven cases of squamous cell carcinoma that resulted from chronic chromoblastomycosis in the Brazilian Amazon state Maranhão.

“There appears to be remarkable polymorphism in the presentation of [chromoblastomycosis] lesions, where the most aggressive and disabling manifestation is possible malignant transformation,” the researchers wrote in Clinical Infectious Diseases. “However, this extreme is considered rare by some authors, probably due to the lower number of reports to date. Here we demonstrate that malignancy may be more common in [chromoblastomycosis] than shown by current data.”

FDA News

FDA issues update on Sunscreen Innovation Act

February 26, 2015
The FDA has issued additional information on the agency’s review of sunscreen ingredients and the Sunscreen Innovation Act.Congress enacted the Sunscreen…

FTC announces settlements against marketers of apps claiming utility in early melanoma detection

February 24, 2015
The Federal Trade Commission announced that the marketers of MelApp and Mole Detective have agreed to settlements that bar them from deceptively claiming their mobile…
FDA News

FDA grants marketing authorization for direct-to-consumer genetic test for Bloom syndrome

February 20, 2015
The FDA has authorized marketing of 23andMe’s Bloom Syndrome Carrier Status test, a direct-to-consumer genetic test that could determine whether a healthy person…
CME
PD-1 Antibodies

PD-1 Antibodies

This activity is supported by educational grants from Bristol-Myers Squibb, Delcath Systems, Inc., Merck & Co., Inc., OncoSec Medical, Inc., Prometheus and Provectus Pharmaceuticals, Inc.

This activity will review data on the efficacy, safety, and response patterns observed with PD-1 in patients with…
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CME
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Targeted Therapy and Immunotherapy in the Management of Metastatic Melanoma: 2014 Updates

This activity is supported by an educational grant from Merck & Co., Inc.

Melanoma remains a challenging condition for clinicians. An array of targeted therapies and immunotherapy are in…
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In the Journals

Chronic fungal lesions predisposed to malignancy

March 2, 2015
Researchers in Brazil documented seven cases of squamous cell carcinoma that resulted from chronic chromoblastomycosis in the Brazilian Amazon state…
FDA News

FDA issues update on Sunscreen Innovation Act

February 26, 2015
The FDA has issued additional information on the agency’s review of sunscreen ingredients and the Sunscreen Innovation Act.Congress enacted the…

FTC announces settlements against marketers of apps claiming utility in early melanoma detection

February 24, 2015
The Federal Trade Commission announced that the marketers of MelApp and Mole Detective have agreed to settlements that bar them from deceptively…
FDA News

FDA grants marketing authorization for direct-to-consumer genetic test for Bloom syndrome

February 20, 2015
The FDA has authorized marketing of 23andMe’s Bloom Syndrome Carrier Status test, a direct-to-consumer genetic test that could determine…
In the Journals

SLNB indicated for thick, clinically lymph node-negative melanoma

February 20, 2015
Patients with thick melanoma who had a negative sentinel lymph node biopsy had prolonged RFS, disease-specific survival and OS, according to study…
In the Journals

Patients with familial, sporadic melanoma have elevated risk for next melanoma

February 19, 2015
Patients with either familial or sporadic melanoma had a two- to three-times elevated risk for next melanoma based on the number of previous…
In the Journals

Advanced melanoma therapy should continue beyond disease progression

February 19, 2015
Continued use of vemurafenib, even after disease progression, can improve survival outcomes for patients with BRAF V600-mutated advanced…
FDA NewsDrug Pipeline

FDA grants priority review to cobimetinib combined with Zelboraf for advanced melanoma

February 19, 2015
The FDA today has granted priority review to cobimetinib in combination with vemurafenib for the treatment of patients with BRAF V600-positive…
Jerry D. Brewer, MD In the Journals

Mohs' micrographic surgery effective for primary mucinous carcinoma of skin

February 16, 2015
Mohs' micrographic surgery appeared to reduce recurrence rates and improve outcomes in patients with primary mucinous carcinoma of the skin…
In the Journals

Pretreatment affects outcomes in patients with metastatic melanoma

February 12, 2015
Prior treatment appeared to considerably affect how of patients with stage IV metastatic melanoma responded to vemurafenib therapy, according to…
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