NEW ORLEANS — An erythroid factor that represses hepcidin during increased erythropoietic activity may contribute to the pathogenesis of iron-loading anemias, including beta-thalassemia, according to study findings presented at the ASH Annual Meeting and Exhibition.
“We identified a new protein that may be the erythroid regulator described a few decades ago,” Leon Kautz, MD, PhD, of the University of California at Los Angeles, told HemOnc Today. “We show that erythroferrone is the erythroid factor coordinating iron supply for erythropoiesis. Erfe functions by suppressing the production of the iron-regulatory hormone hepcidin. However, further work is required to definitely answer whether Erfe is ‘the’ erythroid regulator or ‘an’ erythroid regulator.”More »