Top Story

Somatic mutations in myelodysplastic syndrome linked to shorter survival after HSCT

August 18, 2014

Patients with myelodysplastic syndrome who harbored TP53, TET2 or DNMT3A mutations demonstrated significantly shorter OS after allogeneic hematopoietic stem-cell transplantation, according to study results.

Rafael Bejar, MD, PhD, assistant professor of medicine at University of California, San Diego, and colleagues evaluated tumor samples from 87 patients (median age, 58 years) before they underwent HSCT. Researchers used massively parallel sequencing to evaluate the samples for 40 genes commonly mutated in myelodysplastic syndrome.

figure In the Journals

Genetic mutation linked to acquired ibrutinib resistance in MCL

August 15, 2014
A relapse-specific BTK genetic mutation identified in patients with mantle cell lymphoma may serve as a target to overcome both primary and acquired ibrutinib…
Industry News

Kyprolis fails to meet primary endpoint in multiple myeloma

August 15, 2014
Results from a phase 3 trial have found that carfilzomib did not meet its primary endpoint of OS for the treatment of relapsed and advanced refractory multiple myeloma…
figure In the Journals

Switch from imatinib to nilotinib improved outcomes in chronic phase CML

August 15, 2014
Patients with chronic phase chronic myeloid leukemia who had persistent minimal residual disease after long-term treatment with imatinib achieved deeper molecular…

MPN Updates

This electronic newsletter is sponsored by Incyte Corp. through a third-party independent grant.

1/8/2014
As the standards of care for patients with myeloproliferative neoplasms (MPNs) continue to evolve, physicians must stay…
More »
CME

Obesity and Comorbidities: Improving Clinical Management and Patient Outcomes in Obesity, Diabetes and Cancer

This activity is supported by an educational grant from Eisai, Inc.

11/13/2013
Obesity has increased dramatically in the past 20 years, and is considered a healthcare epidemic in the United States…
More »

Filter By:

In the Journals

Somatic mutations in myelodysplastic syndrome linked to shorter survival after HSCT

August 18, 2014
Patients with myelodysplastic syndrome who harbored TP53, TET2 or DNMT3A mutations demonstrated significantly shorter OS after allogeneic…
figure In the Journals

Genetic mutation linked to acquired ibrutinib resistance in MCL

August 15, 2014
A relapse-specific BTK genetic mutation identified in patients with mantle cell lymphoma may serve as a target to overcome both primary and acquired…
Industry News

Kyprolis fails to meet primary endpoint in multiple myeloma

August 15, 2014
Results from a phase 3 trial have found that carfilzomib did not meet its primary endpoint of OS for the treatment of relapsed and advanced…
figure In the Journals

Switch from imatinib to nilotinib improved outcomes in chronic phase CML

August 15, 2014
Patients with chronic phase chronic myeloid leukemia who had persistent minimal residual disease after long-term treatment with imatinib achieved…
figure FDA News

FDA grants fast track designation to AG-221 for IDH2-mutant AML

August 14, 2014
The FDA granted fast track designation to AG-221 as a potential treatment for patients with acute myelogenous leukemia who harbor IDH2 genetic…
In the Journals Perspective

Higher BMI increased risk for 10 common cancers

August 13, 2014
Higher BMI increased individuals’ risks for 10 common cancers, according to results of a population-based cohort study conducted in the United…
figure FDA News

FDA grants orphan drug status to mocetinostat for DLBCL

August 11, 2014
The FDA granted orphan drug designation to mocetinostat for the treatment of patients with diffuse large B-cell lymphoma, its manufacturer announced…
figure FDA approvals

FDA approves Velcade for multiple myeloma retreatment

August 11, 2014
The FDA today approved bortezomib for the retreatment of adults with multiple myeloma who previously responded to bortezomib but relapsed at least 6…
figure In the Journals

Noninvasive tool identified high coronary artery disease burden in childhood cancer survivors

August 8, 2014
Coronary CT angiography identified coronary artery disease in a high percentage of adult survivors of childhood Hodgkin’s lymphoma, according…
FDA News

FDA grants fast track designation to pacritinib for myelofibrosis

August 8, 2014
The FDA granted fast track designation to pacritinib as a potential treatment for patients with intermediate- and high-risk myelofibrosis, its…
More Headlines »