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Addition of monoclonal antibody to reduced-intensity conditioning regimen effective in advanced B-cell lymphoma

December 18, 2014

The addition of the CD20-directed monoclonal antibody 90Y-Ibritumomab tiuxetan to a reduced-intensity fludarabine-based conditioning regimen followed by allogeneic transplantation appeared safe and effective in patients with chemosensitive advanced high-risk B-cell lymphoma, according to results of a multicenter phase 2 trial.

Patients with advanced B-cell non-Hodgkin’s lymphoma who are refractory to initial chemotherapy or relapse after autologous stem cell transplant have a poor prognosis. Transplantation after a reduced-intensity conditioning regimen may be an effective therapeutic option, yet the high incidence for relapse remains a formidable challenge, according to background information provided by researchers.

Meeting News CoveragePerspective

Early thymic precursor immunophenotype does not affect T-cell ALL outcomes

December 18, 2014
SAN FRANCISCO — Children with T-cell acute lymphoblastic leukemia achieved favorable 5-year EFS and OS outcomes regardless of whether they expressed the early…
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Data show encouraging advances in treatment of AML

December 17, 2014
SAN FRANCISCO – According to preliminary data presented at the ASH Annual Meeting and Exposition, FLT3 inhibitors have been shown to have a dramatic, positive…
In the Journals

Entecavir decreased HBV incidence, reactivation in patients undergoing R-CHOP for lymphoma

December 16, 2014
In a new phase 3 study, patients seropositive for the hepatitis B surface antigen with diffuse large B-cell lymphoma who underwent chemotherapy with rituximab plus CHOP…
CME
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Targeted Therapy and Immunotherapy in the Management of Metastatic Melanoma: 2014 Updates

This activity is supported by an educational grant from Merck & Co., Inc.

Melanoma remains a challenging condition for clinicians. An array of targeted therapies and immunotherapy are in…
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Meeting News Coverage Video
Epigenetics research prompts hope for improved treatment of acute myeloid leukemia

Epigenetics research prompts hope for improved treatment of acute myeloid leukemia

December 12, 2014
SAN FRANCISCO – Epigenetics appears to be the next area of development researchers will focus on in the mission…
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CME
New Advances, New Options: Evaluating the Changing Landscape of Hemophilia

New Advances, New Options: Evaluating the Changing Landscape of Hemophilia to Optimize Patient Outcomes

This activity is supported by an educational grant from Biogen Idec.

The bleeding abnormalities associated with hemophilia can have devastating consequences for patients. Recent advances…
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In the Journals

Addition of monoclonal antibody to reduced-intensity conditioning regimen effective in advanced B-cell lymphoma

December 18, 2014
The addition of the CD20-directed monoclonal antibody 90Y-Ibritumomab tiuxetan to a reduced-intensity fludarabine-based conditioning regimen followed…
Meeting News CoveragePerspective

Early thymic precursor immunophenotype does not affect T-cell ALL outcomes

December 18, 2014
SAN FRANCISCO — Children with T-cell acute lymphoblastic leukemia achieved favorable 5-year EFS and OS outcomes regardless of whether they…
thumbnail for video 3949008667001 Meeting News CoverageVideo

Data show encouraging advances in treatment of AML

December 17, 2014
SAN FRANCISCO – According to preliminary data presented at the ASH Annual Meeting and Exposition, FLT3 inhibitors have been shown to have a…
In the Journals

Entecavir decreased HBV incidence, reactivation in patients undergoing R-CHOP for lymphoma

December 16, 2014
In a new phase 3 study, patients seropositive for the hepatitis B surface antigen with diffuse large B-cell lymphoma who underwent chemotherapy with…
Karen Midthun FDA News

FDA approves supplemental HTLV-I/II test

December 15, 2014
The FDA has approved MP Biomedicals’ supplemental confirmation test for human T-cell lymphotropic virus types I and II, according to a press …
Epigenetics research prompts hope for improved treatment of acute myeloid leukemia Meeting News CoverageVideo

Epigenetics research prompts hope for improved treatment of acute myeloid leukemia

December 12, 2014
SAN FRANCISCO – Epigenetics appears to be the next area of development researchers will focus on in the mission to improve the current standard…
Meeting News CoveragePerspective

Lenalidomide targets CSNK1A1 in myelodysplastic syndrome with del(5q)

December 10, 2014
SAN FRANCISCO — Lenalidomide appears to be effective in myelodysplastic syndrome with the deletion of chromosome 5q through the ubiquitination…
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Pediatric ALL treatment regimens improved outcomes among AYA population

December 10, 2014
SAN FRANCISCO — Joseph Alvarnas, MD, from the department of hematology and hematopoietic cell transplantation at The City of Hope, highlights…
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Perceived QoL impacted survival in patients with aggressive lymphoma

December 10, 2014
SAN FRANCISCO — Carrie A. Thompson, MD, from the division of hematology at Mayo Clinic, discusses study results which found that perceived…
In the Journals

Current smoking linked to invasive fusariosis in patients with acute myeloid leukemia

December 10, 2014
Researchers at the Universidade Federal do Rio de Janeiro in Brazil determined that active smoking was associated with invasive fusariosis among…
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