Head/Neck Cancer

Top Story

NOTCH1 mutations define aggressive subtype of adenoid cystic carcinomas

February 13, 2017

NOTCH1 mutations defined a subgroup of patients with adenoid cystic carcinomas who harbored an aggressive disease phenotype, demonstrated a distinct pattern of metastatic spread, and who may be responsive to Notch1 inhibitors, according to a study published in Journal of Clinical Oncology.
— common malignant salivary gland tumors — are characterized as a heterogeneous group of chemotherapy-refractory tumors, a subset of which have an aggressive phenotype. No standard of care exists for patients with recurrent or metastatic disease.

“Whole-exome sequencing of adenoid cystic carcinomas samples has shed light on the genetic landscape of this disease and provides evidence for Notch pathway alterations in 11% to 29% of patients,” Renata Ferrarotto, MD, assistant professor in the department of thoracic/head and neck medical oncology at The University of Texas MD Anderson Cancer Center, and colleagues wrote. “The Notch pathway is involved in cancer-relevant functions, including maintenance of stem cells, cell fate specification, proliferation and angiogenesis.”

FDA: More adolescents with cancer should be included in adult trials

February 13, 2017
Enrollment of adolescents in oncology trials remains significantly lower than that of children. Consequently, the FDA has urged the research community to enroll more…
In the Journals Plus

Use of metaphors may improve participation in clinical trials

February 11, 2017
The use of metaphors for explaining randomization could ease the difficulty in recruiting patients to participate in randomized clinical trials, according to a study…

‘Explosive growth’ of interventional oncology prompts formation of new society

February 10, 2017
The board of directors for World Conference on Interventional Oncology, a nonprofit association that supports and promotes the field, has established a society to…
CME

The Patient with Castration-resistant Prostate Cancer

No commercial support for this activity.

Castration-resistant prostate cancer (CRPC) is a heterogeneous condition that encompasses a continuum of disease…
More »
Video
Meeting News Coverage

VIDEO: Less surgery, active surveillance viable option for low-risk thyroid cancer

September 22, 2016
More »
Featured
In the Journals Plus

NOTCH1 mutations define aggressive subtype of adenoid cystic carcinomas

February 13, 2017
NOTCH1 mutations defined a subgroup of patients with adenoid cystic carcinomas who harbored an aggressive disease phenotype, demonstrated a distinct…

FDA: More adolescents with cancer should be included in adult trials

February 13, 2017
Enrollment of adolescents in oncology trials remains significantly lower than that of children. Consequently, the FDA has urged the research…

In the Journals Plus

Use of metaphors may improve participation in clinical trials

February 11, 2017
The use of metaphors for explaining randomization could ease the difficulty in recruiting patients to participate in randomized clinical trials…

‘Explosive growth’ of interventional oncology prompts formation of new society

February 10, 2017
The board of directors for World Conference on Interventional Oncology, a nonprofit association that supports and promotes the field, has established…

Eight updates in cancer prevention

February 10, 2017
National Cancer Prevention Month, established by a U.S. Senate resolution and observed every February since 2004, is intended to draw attention to…

In the Journals Plus

Addition of cetuximab improves outcomes in KRAS-variant HNSCC

February 9, 2017
Adding cetuximab to radiotherapy and cisplatin significantly improved PFS and OS in patients with KRAS-variant head and neck squamous cell

Payment reform, ‘runaway growth’ of 340B top new Community Oncology Alliance president’s priorities

February 9, 2017
Jeff Vacirca, MD, FACP, CEO and managing director of clinical research at New York Cancer Specialists in Long Island, N.Y., has been elected…

Better physician–patient communication needed about costs of cancer care

February 7, 2017
Physicians’ willingness to communicate with patients about the cost of cancer care appeared associated with improved patient satisfaction and…

ACS endorses two-dose HPV vaccination schedule

February 7, 2017
The American Cancer Society endorsed the updated recommendations from the Advisory Committee on Immunization Practices that support a two-dose…

In the Journals

ACIP updates adult immunization schedule for influenza, HPV, HBV, meningococcal vaccines

February 6, 2017
The Advisory Committee on Immunization Practices released its 2017 Recommended Immunization Schedule for adults aged 19 years and older, including…

More Headlines »
Advertisement
Advertisement