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Baseline caspase levels may serve as biomarker in advanced SCCHN

July 1, 2015

The presence of high serum caspase-3 activity predicted poor PFS and nonresponse to novel targeted treatments in patients with squamous cell cancer of the head and neck, according to study results.

Mounting evidence suggests that mTOR inhibitors might effectively treat advanced squamous cell carcinoma of the head and neck (SCCHN). However, noninvasive biomarkers for early prediction of treatment efficacy have not been identified, according to study background.

David J. Adelstein, MD, FACP In the Journals

Nonsurgical treatment may be viable option for advanced laryngeal cancer

June 29, 2015
Nonsurgical treatment for larynx preservation resulted in a greater incidence of recurrence compared with surgery in patients with advanced supraglottic laryngeal…
Ana Maia In the Journals

Differentiated thyroid cancer recurrence rates low after initial therapy

June 24, 2015
Patients with differentiated thyroid cancer who were disease-free after their initial treatment were likely to stay disease-free at long-term follow-up, according to…
Meeting News Coverage

Mutational profiles of HPV-positive, HPV-negative tumors differ

June 18, 2015
CHICAGO — The differences in the genetic profile of HPV-positive and HPV-negative tumors may represent therapeutic targets for cancers of the pharynx and oral…
CME
Hematology Oncology Case Consults

The Patient with Chronic Lymphocytic Leukemia

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of patients with chronic lymphocytic leukemia.
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Meeting News Coverage Video
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VIDEO: Ethical issues arise in genetic screening of thyroid cancer

March 7, 2015
SAN DIEGO — In this video exclusive, M. Sara Rosenthal, MD, director of the program for bioethics at the…
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CME CNE
High Risk AAMDS

Treatment Decision-Making through the Spectrum of MDS:
Case 2 High Risk MDS

An educational presentation from Aplastic Anemia & MDS International Foundation.

MDS is a difficult disease to diagnose and treat. Frequently it is challenging for healthcare providers to explain to…
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In the Journals

Baseline caspase levels may serve as biomarker in advanced SCCHN

July 1, 2015
The presence of high serum caspase-3 activity predicted poor PFS and nonresponse to novel targeted treatments in patients with squamous cell cancer…
David J. Adelstein, MD, FACP In the Journals

Nonsurgical treatment may be viable option for advanced laryngeal cancer

June 29, 2015
Nonsurgical treatment for larynx preservation resulted in a greater incidence of recurrence compared with surgery in patients with advanced…
Ana Maia In the Journals

Differentiated thyroid cancer recurrence rates low after initial therapy

June 24, 2015
Patients with differentiated thyroid cancer who were disease-free after their initial treatment were likely to stay disease-free at long-term…
Meeting News Coverage

Mutational profiles of HPV-positive, HPV-negative tumors differ

June 18, 2015
CHICAGO — The differences in the genetic profile of HPV-positive and HPV-negative tumors may represent therapeutic targets for cancers of the…
Meeting News CoveragePerspective

Induction chemotherapy with docetaxel preserves larynx function in squamous cell carcinoma

June 15, 2015
CHICAGO — The addition of docetaxel to induction chemotherapy with cisplatin and 5-fluorouracil prolonged larynx preservation and larynx…
In the Journals

Death rates remain high among cancers caused by cigarette smoking

June 15, 2015
Despite significantly decreasing rates of smoking over the past 50 years, cigarette smoking continues to be the cause of death for various types of…
In the Journals

Primary surgery may improve advanced-stage hypopharyngeal squamous cell carcinoma outcomes

June 8, 2015
Patients with advanced-stage hypopharyngeal squamous cell carcinoma who underwent surgical management demonstrated a trend toward clinically improved…
Meeting News CoveragePerspective

Elective neck dissection improves survival in early-stage oral cancer

June 1, 2015
CHICAGO – The prophylactic removal of lymph nodes during primary surgery improves survival and reduces the rate of recurrence in early-stage…
Drug PipelinePerspectivePublication Exclusive

2015 Oncology Drugs in the Pipeline

HemOnc Today, May 25, 2015
HemOnc Today’s annual Oncology Drugs in the Pipeline chart lists agents in phase 2 or phase 3 development for a variety of indications. Clinicians…
Tanguy Seiwert, MD Meeting News CoveragePerspective

Pembrolizumab demonstrates efficacy in advanced head and neck cancers

May 29, 2015
CHICAGO — The anti–PD-1 antibody pembrolizumab demonstrated strong activity in patients with recurrent or metastatic head and neck…
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