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Novel mutation detected in nearly 20% of colorectal, endometrial cancers

October 26, 2014

Somatic mutations of RNF43 were detected in nearly one of every five colorectal cancers and endometrial cancers, a finding that suggests the novel mutation is one of the most frequent in these cancers, according to study results.

Marios Giannakis, MD, PhD, instructor in medicine at Dana-Farber Cancer Institute and researcher at the Broad Institute of MIT and Harvard, and colleagues conducted whole-exome sequencing on 185 colorectal tumor and matched DNA samples from participants in the Nurses’ Health Study and the Health Professionals Follow-up Study.

In the Journals

Maintenance pazopanib extended PFS, not OS in ovarian cancer

October 24, 2014
Maintenance therapy with pazopanib extended PFS by about 45% among women with ovarian cancer whose disease did not progress during first-line chemotherapy, according to…
In the Journals

Brief intervention improved sexual function after oophorectomy

October 24, 2014
Women with the BRCA1 or BRCA2 mutations who underwent risk-reducing salpingo oophorectomy and experienced menopause-related sexual dysfunction and associated…
figure Meeting News Coverage

Olaparib tablet shows promise in pretreated ovarian cancer

October 23, 2014
Oral olaparib tablets combined with a weekly regimen of carboplatin and paclitaxel was safe for use in patients with advanced ovarian cancer who have failed to respond…
CME CNE
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Treatment Decision-Making through the Spectrum of MDS: Case 3 Stem Cell Transplant for MDS

An educational presentation from Aplastic Anemia & MDS International Foundation.

MDS is a difficult disease to diagnose and treat. Frequently it is challenging for healthcare providers to explain to…
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CME CNE
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Treatment Decision-Making through the Spectrum of MDS: Case 1 Low Risk MDS

An educational presentation from Aplastic Anemia & MDS International Foundation.

MDS is a difficult disease to diagnose and treat. Frequently it is challenging for healthcare providers to explain MDS…
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figure In the Journals

Novel mutation detected in nearly 20% of colorectal, endometrial cancers

October 26, 2014
Somatic mutations of RNF43 were detected in nearly one of every five colorectal cancers and endometrial cancers, a finding that suggests the novel…
In the Journals

Maintenance pazopanib extended PFS, not OS in ovarian cancer

October 24, 2014
Maintenance therapy with pazopanib extended PFS by about 45% among women with ovarian cancer whose disease did not progress during first-line…
In the Journals

Brief intervention improved sexual function after oophorectomy

October 24, 2014
Women with the BRCA1 or BRCA2 mutations who underwent risk-reducing salpingo oophorectomy and experienced menopause-related sexual dysfunction and…
figure Meeting News Coverage

Olaparib tablet shows promise in pretreated ovarian cancer

October 23, 2014
Oral olaparib tablets combined with a weekly regimen of carboplatin and paclitaxel was safe for use in patients with advanced ovarian cancer who have…
FDA News

FDA grants aldoxorubicin orphan drug status

October 1, 2014
CytRx Corp. announced that the FDA granted multiple orphan drug designation to aldoxorubicin for the treatment of patients with glioblastoma…
figure In the Journals

Effective implementation of nine-valent HPV vaccination could prevent majority of cervical cancers

October 1, 2014
Most cervical precancers appear to be caused by one of nine types of HPV, according to study results.The findings suggest an investigational…
figure In the Journals Perspective

Multidisciplinary approach may better detect, treat depression among patients with cancer

HemOnc Today, October 25, 2014
Major depression is common among patients with cancer — particularly those with lung cancer — yet it often goes untreated, according to a series of…
In the Journals

Lenalidomide active in recurrent ovarian cancer

September 30, 2014
Continuous treatment with lenalidomide demonstrated activity in women with late recurrent ovarian cancer, according to results of a phase 2 study…
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Quest for clinically meaningful PFS benefit an ‘imperfect science’

HemOnc Today, September 25, 2014
Small improvements in study endpoints often serve as the foundation for drug approvals.However, a small but vocal segment of the hematology and…
In the Journals Perspective

IBD showed link with cervical neoplasia

September 23, 2014
A reciprocal association existed between inflammatory bowel disease, particularly Crohn’s disease, and cervical neoplasia in a recent study.In…
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