Gynecologic Cancer

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BRCA1 mutations linked to increased risk for serous, serous-like endometrial carcinoma

<i>BRCA1</i> mutations linked to increased risk for serous, serous-like endometrial carcinoma
June 30, 2016

Women who harbored a BRCA1 mutation had increased risk for serous and serous-like endometrial carcinoma following risk-reducing salpingo-oophorectomy, according to the results of a prospective cohort study.

Although risk-reducing salpingo-oophorectomy is standard for women who harbor BRCA mutations, the role of concomitant hysterectomy is controversial because the risk for uterine cancer in this cohort had been unclear. Some studies had suggested that the risk for uterine corpus cancer in these women was linked to tamoxifen citrate use.

Meeting News Coverage

Biden: A decade’s worth of cancer research possible in half the time

June 29, 2016
PHILADELPHIA — Fox Chase Cancer Center today hosted a Regional Cancer Moonshot Summit in conjunction with the National Cancer Moonshot Summit held in Washington…

AACR president: ‘Full spectrum’ of cancer research must remain priority

June 29, 2016
Nancy E. Davidson, MD, director of University of Pittsburgh Cancer Institute, took over as president of the American Association for Cancer Research this spring…

Niraparib extends PFS in ovarian cancer

June 29, 2016
Niraparib significantly extended PFS compared with placebo among women with recurrent ovarian cancer, according to phase 3 study results released today by the…
CME

The Patient with Myelofibrosis

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Myelofibrosis is caused by abnormal stem cells in the bone marrow that cause the uncontrolled production of mature…
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Meeting News Coverage

Antibody-drug conjugate shows promise for NSCLC, ovarian cancer

June 12, 2014
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2016 ASCO Annual Meeting

2016 ASCO Annual Meeting

CME

The Patient with Multiple Ecchymoses

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Glanzmann’s thrombasthenia is a rare, inherited bleeding disorder that results from a mutation in αIIbß3, an integrin…
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In the Journals

BRCA1 mutations linked to increased risk for serous, serous-like endometrial carcinoma

June 30, 2016
Women who harbored a BRCA1 mutation had increased risk for serous and serous-like endometrial carcinoma following risk-reducing…

Meeting News Coverage

Biden: A decade’s worth of cancer research possible in half the time

June 29, 2016
PHILADELPHIA — Fox Chase Cancer Center today hosted a Regional Cancer Moonshot Summit in conjunction with the National Cancer Moonshot Summit…

AACR president: ‘Full spectrum’ of cancer research must remain priority

June 29, 2016
Nancy E. Davidson, MD, director of University of Pittsburgh Cancer Institute, took over as president of the American Association for Cancer Research…

Niraparib extends PFS in ovarian cancer

June 29, 2016
Niraparib significantly extended PFS compared with placebo among women with recurrent ovarian cancer, according to phase 3 study results released…

FDA’s cancer drug director to lead Oncology Center of Excellence

June 29, 2016
Richard Pazdur, MD, director of the Office of Hematology and Oncology Products in the FDA’s Center for Drug Evaluation, has been named acting…

In the Journals

Telephone counseling effectively reaches women with hereditary cancer risk

June 29, 2016
Telephone counseling provided genetic services for women at high risk for hereditary breast and ovarian cancer as well as in-person counseling…

Task force: Evidence insufficient to determine benefits, harms of routine screening pelvic exams

June 28, 2016
No direct evidence supports the overall benefits or harms of one-time or periodic screening pelvic examinations for potential gynecologic conditions…

Eight updates about how lifestyle affects cancer risk, outcomes

June 27, 2016
Lifestyle choices can contribute considerably to a person’s cancer risk, as well the outcomes they achieve after they are diagnosed with a…

In the JournalsPerspective

Novel fluorescent agent may identify ovarian lesions during surgery

June 27, 2016
The use of a real-time intraoperative tumor-specific fluorescent agent and imaging system aided surgeons in identifying and removing tumors not…

At IssueVideo

VIDEO: Toxicities related to immune therapies ‘unpredictable’ but ‘manageable’

June 23, 2016
James P. Allison, PhD, chair of the department of immunology and executive director of the immunotherapy platform at MD Anderson Cancer Center in…

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