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VEGF inhibitors not effective for locally advanced kidney cancer

February 24, 2015

Although the VEGF inhibitors sorafenib and sunitinib are widely used and typically effective in the treatment of metastatic kidney cancer, use of the agents in the adjuvant setting did not improve outcomes for patients with locally advanced kidney cancer, according to study results presented at the Genitourinary Cancers Symposium.

An interim analysis of data from the phase 3 ASSURE trial indicated that these agents did not reduce disease recurrence; however, they did not worsen patient outcomes, either.

In the Journals

Extra-virgin olive oil ingredient rapidly induces cancer cell death

February 19, 2015
Oleocanthal, an ingredient found in extra-virgin olive oil, induces cancer cell death without harming noncancerous cells, according to study results.“Compounds…
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MET targeting, PD-L1/PD-1 inhibition highlight recent developments in genitourinary oncology

February 11, 2015
Derek Raghavan, MD, PhD, FACP, FRACP, FASCO, president of Levine Cancer Institute at Carolinas HealthCare System and HemOnc Today's Chief Medical Editor for…
In the Journals

Large retroperitoneal lymphadenopathy predicted VTE risk in disseminated germ cell tumors

February 5, 2015
Large retroperitoneal lymph nodes demonstrated greater discriminatory accuracy than a high-risk Khorana score for the prediction of risk for chemotherapy-associated…
CME CNE
Stem Cell Transplant for AAMDS

Treatment Decision-Making through the Spectrum of MDS:
Case 3 Stem Cell Transplant for MDS

An educational presentation from Aplastic Anemia & MDS International Foundation.

MDS is a difficult disease to diagnose and treat. Frequently it is challenging for healthcare providers to explain to…
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CME
Activity cover

Targeted Therapy and Immunotherapy in the Management of Metastatic Melanoma: 2014 Updates

This activity is supported by an educational grant from Merck & Co., Inc.

Melanoma remains a challenging condition for clinicians. An array of targeted therapies and immunotherapy are in…
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Naomi B. Haas, MD Meeting News Coverage

VEGF inhibitors not effective for locally advanced kidney cancer

February 24, 2015
Although the VEGF inhibitors sorafenib and sunitinib are widely used and typically effective in the treatment of metastatic kidney cancer, use of the…
In the Journals

Extra-virgin olive oil ingredient rapidly induces cancer cell death

February 19, 2015
Oleocanthal, an ingredient found in extra-virgin olive oil, induces cancer cell death without harming noncancerous cells, according to study…
thumbnail for video 4040847621001 Video

MET targeting, PD-L1/PD-1 inhibition highlight recent developments in genitourinary oncology

February 11, 2015
Derek Raghavan, MD, PhD, FACP, FRACP, FASCO, president of Levine Cancer Institute at Carolinas HealthCare System and HemOnc Today's Chief…
In the Journals

Large retroperitoneal lymphadenopathy predicted VTE risk in disseminated germ cell tumors

February 5, 2015
Large retroperitoneal lymph nodes demonstrated greater discriminatory accuracy than a high-risk Khorana score for the prediction of risk for…
Toni K. Choueiri, MD In the Journals

PD-L1 expression, CD8+ T-cell counts associated with shorter OS in mRCC

January 28, 2015
Higher levels of PD-L1 expression, as well as PD-L1 expression plus tumor CD8+ T-cell counts, were linked to shorter survival in patients with…
Association News

Bladder Cancer Advocacy Network announces award recipients

January 22, 2015
The Bladder Cancer Advocacy Network (BCAN) named William Kim, MD, the recipient of its 2014 Bladder Cancer Research Innovation Award.Kim, associate…
Robert J. Motzer, MD In the Journals

Nivolumab showed antitumor activity in patients with metastatic renal cell carcinoma

January 13, 2015
Nivolumab showed antitumor activity with a manageable safety profile in previously treated patients with clear-cell metastatic renal cell carcinoma…
Cora Sternberg In the Journals

Immediate chemotherapy after radical cystectomy failed to extend OS

January 8, 2015
Patients with urothelial carcinoma of the bladder who underwent immediate chemotherapy after radical cystectomy or bilateral lymphadenectomy…
Michael Hauptmann, PhD In the Journals

Radiotherapy for testicular cancer increased risk for subsequent stomach cancer

January 6, 2015
Survivors of testicular cancer who underwent abdominal radiotherapy demonstrated long-term elevated risk for subsequent stomach cancers, according to…
In the Journals

Bisphosphonate prescriptions low among men who underwent ADT

January 2, 2015
Although guidelines recommend bisphosphonates for men who initiate androgen deprivation therapy, prescriptions for these agents in this patient…
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