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Molecular subtypes of stage III colon cancer linked to different patient outcomes

January 30, 2015

Researchers have identified subtypes of stage III colon cancer based on molecular markers associated with differences in clinical and pathological features as well as disease-free survival.

Investigators prospectively collected 2,720 stage III colon cancer samples from participants in an adjuvant chemotherapy trial. They used a polymerase chain reaction-based assay to identify mutations in BRAF (V600E) and KRAS oncogenes, and identified tumors deficient or proficient in DNA mismatch repair (MMR) based on detection of MLH1, MSH2 and MSH6 proteins and MLH1 methylation. Then they characterized tumor subtypes into five groups with respect to clinicopathologic features and rates of disease-free survival (DFS), and validated the findings using separate tumor samples from 783 other patients with stage III cancer.

In the JournalsPerspective

GTX effective neoadjuvant treatment in locally advanced pancreatic cancer

January 29, 2015
Patients with locally advanced, unresectable pancreatic adenocarcinoma experienced favorable survival when they received neoadjuvant gemcitabine, docetaxel and…
FDA NewsDrug Pipeline

Tarextumab granted orphan drug designation for pancreatic, small cell lung cancers

January 29, 2015
The FDA granted orphan drug designation to tarextumab for the treatment of pancreatic cancer and small cell lung cancer, the drug’s manufacturer announced…
In the Journals

Confocal laser endomicroscopy improved detection of biliary cancer

January 28, 2015
When combined with tissue sampling, using probe-based confocal laser endomicroscopy during endoscopic retrograde cholangio-pancreatography diagnosed cholangiocarcinoma…
CME
New Advances, New Options: Evaluating the Changing Landscape of Hemophilia

New Advances, New Options: Evaluating the Changing Landscape of Hemophilia to Optimize Patient Outcomes

This activity is supported by an educational grant from Biogen Idec.

The bleeding abnormalities associated with hemophilia can have devastating consequences for patients. Recent advances…
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CME CNE
Low Risk AAMDS

Treatment Decision-Making through the Spectrum of MDS:
Case 1 Low Risk MDS

An educational presentation from Aplastic Anemia & MDS International Foundation.

MDS is a difficult disease to diagnose and treat. Frequently it is challenging for healthcare providers to explain MDS…
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In the Journals

Molecular subtypes of stage III colon cancer linked to different patient outcomes

January 30, 2015
Researchers have identified subtypes of stage III colon cancer based on molecular markers associated with differences in clinical and pathological…
In the JournalsPerspective

GTX effective neoadjuvant treatment in locally advanced pancreatic cancer

January 29, 2015
Patients with locally advanced, unresectable pancreatic adenocarcinoma experienced favorable survival when they received neoadjuvant gemcitabine…
FDA NewsDrug Pipeline

Tarextumab granted orphan drug designation for pancreatic, small cell lung cancers

January 29, 2015
The FDA granted orphan drug designation to tarextumab for the treatment of pancreatic cancer and small cell lung cancer, the drug’s…
In the Journals

Confocal laser endomicroscopy improved detection of biliary cancer

January 28, 2015
When combined with tissue sampling, using probe-based confocal laser endomicroscopy during endoscopic retrograde cholangio-pancreatography diagnosed…
Alexandria Phan Meeting News Coverage

Lanreotide shows promise in patients with pancreatic neuroendocrine tumors

January 28, 2015
Lanreotide demonstrated antitumor activity with a manageable safety profile in patients with pancreatic neuroendocrine tumors, according to a…
Jason A. Zell, DO, MPH In the Journals

CRC incidence increasing in young adults

January 27, 2015
The incidence of colorectal cancer is increasing among the young adult population while decreasing among adults in the screened population, according…
Meeting News Coverage

Pembrolizumab appears safe, effective in advanced gastric cancer

January 27, 2015
The novel agent pembrolizumab demonstrated promising antitumor activity and manageable toxicity in patients with advanced gastric cancer, according…
Kim F. Rhoads, MD In the Journals

Integrated health care may eliminate racial disparities in colon cancer survival

January 26, 2015
Providing fair, high-quality, evidence-based care can eliminate racial disparities in survival outcomes among patients with colon cancer, according…
Meeting News Coverage

MM-398 improved outcomes in metastatic pancreatic cancer

January 23, 2015
The addition of the novel agent MM-398 to second-line 5-FU/leucovorin extended survival in patients with metastatic pancreatic cancer, according to…
Daniel Kaemmerer In the Journals

Somatostatin receptors serve as viable markers in bronchopulmonary neuroendocrine neoplasms

January 23, 2015
Somatostatin receptors may have utility as diagnostic, prognostic and therapeutic markers of bronchopulmonary neuroendocrine neoplasms, according to…
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