Breast cancer patients with triple-negative disease who experienced local or regional recurrence had a nearly threefold risk for subsequent relapse, according to recent findings.
Researchers from several sites in Europe aimed to evaluate outcomes among 279 patients with breast cancer who experienced local or regional recurrence. They assessed tumor biological features when the disease was first diagnosed and at the time of recurrence for all consecutive patients who underwent surgery at the European Institute of Oncology in Milan, Italy, between 1994 and 2005.
The final analysis included 197 patients with local recurrence and 82 patients with regional recurrence. Discordance rates between primary cancer and local or regional recurrence were calculated for these patients. ER expression was linked to a 9% overall discordance rate, whereas PR accounted for a 22% rate and HER-2 was linked to a 4% discordance rate.
Patients with regional recurrence had an increased risk for distant metastasis than local relapse in case of late recurrence (HR=2.76; 95% CI, 1.31-5.85). Higher risks for subsequent relapse (HR=2.87; 95% CI, 1.67-4.91) and death (HR=2.00; 95% CI, 1.25-3.19) also were observed among patients with triple-negative breast cancer at local or regional recurrence.
Earn CME this spring at the HemOnc Today Breast Cancer Review & Perspective meeting to be held March 23-24, 2012 at the Hilton San Diego Bayfront. See details at HemOncTodayBreastCancer.com.