March 24, 2017
Women with multiple endocrine neoplasia type 1 are at greater risk for developing early-onset breast cancer compared with women without the disease, according to findings from a cross-sectional study.
Rachel S. van Leeuwaarde, MD, of the department of endocrine oncology at University Medical Center Utrecht, the Netherlands, and colleagues analyzed data from 138 women with confirmed multiple endocrine neoplasia type 1 (MEN1) or a MEN1 mutation from the Dutch MEN1 cohort, a longitudinal database that includes at least 90% of all Dutch MEN1 patients aged at least 16 years. Women completed either a written or online questionnaire between April 2015 and October 2016 regarding breast cancer-related endocrine risk factors, cancer family history and other known risk factors for breast cancer. Researchers compared the age at breast cancer diagnosis among the MEN1 cohort with the female relatives without MEN1, as well as age of breast cancer onset in the general Dutch population using data from the Netherlands Cancer Registry.