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Double-unit cord-blood transplant failed to extend survival in blood cancers

October 29, 2014

Children and adolescents with hematologic malignancies who underwent double-unit cord-blood transplantation experienced similar survival rates as those who underwent single-unit transplants, according to results of a phase 3 randomized trial.

However, patients who received a single unit of cord blood achieved better platelet recovery and demonstrated a reduced risk for grade III and grade IV acute and extensive chronic graft-versus-host disease (GVHD).

FDA News

FDA grants orphan drug status to Glassia for GVHD

October 29, 2014
The FDA granted orphan drug designation to a liquid alpha-1 proteinase inhibitor for the treatment of patients with graft-versus-host disease following allogeneic bone…
In the Journals

GVHD prophylaxis with single-agent cyclophosphamide effective after allogeneic transplant

October 27, 2014
Post-transplant graft-versus-host disease prophylaxis with single-agent cyclophosphamide appeared safe and effective in patients who underwent conditioning with busulfan…
Institution Notes

Cancer center names BMT director

October 4, 2014
William Tse, MD, has been named director of bone marrow transplantation at the University of Louisville James Graham Brown Cancer Center.Tse also will hold the Marion…
CME CNE
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Treatment Decision-Making through the Spectrum of MDS: Case 2 High Risk MDS

An educational presentation from Aplastic Anemia & MDS International Foundation.

MDS is a difficult disease to diagnose and treat. Frequently it is challenging for healthcare providers to explain to…
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CME
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Targeted Therapy and Immunotherapy in the Management of Metastatic Melanoma: 2014 Updates

This activity is supported by an educational grant from Merck & Co., Inc.

Melanoma remains a challenging condition for clinicians. An array of targeted therapies and immunotherapy are in…
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figure In the Journals

Double-unit cord-blood transplant failed to extend survival in blood cancers

October 29, 2014
Children and adolescents with hematologic malignancies who underwent double-unit cord-blood transplantation experienced similar survival rates as…
FDA News

FDA grants orphan drug status to Glassia for GVHD

October 29, 2014
The FDA granted orphan drug designation to a liquid alpha-1 proteinase inhibitor for the treatment of patients with graft-versus-host disease…
In the Journals

GVHD prophylaxis with single-agent cyclophosphamide effective after allogeneic transplant

October 27, 2014
Post-transplant graft-versus-host disease prophylaxis with single-agent cyclophosphamide appeared safe and effective in patients who underwent…
Institution Notes

Cancer center names BMT director

October 4, 2014
William Tse, MD, has been named director of bone marrow transplantation at the University of Louisville James Graham Brown Cancer Center.Tse also…
figure Institution Notes

Cancer center names director of BMT

HemOnc Today, October 25, 2014
William Tse, MD, has been named director of bone marrow transplantation at the University of Louisville James Graham Brown Cancer Center.Tse also…
figure In the Journals Perspective

HLA-matched donors available for most HSCT candidates

HemOnc Today, September 10, 2014
A majority of hematopoietic stem-cell transplantation candidates who do not have related donors have suitable adult donors or cord-blood units…
In the Journals

Somatic mutations in myelodysplastic syndrome linked to shorter survival after HSCT

August 18, 2014
Patients with myelodysplastic syndrome who harbored TP53, TET2 or DNMT3A mutations demonstrated significantly shorter OS after allogeneic…
figure In the Journals

Sirolimus failed to reduce GVHD rates after HSCT

August 13, 2014
The incidence of graft-versus-host disease after related donor allogeneic hematopoietic stem cell transplantation was similar among patients who…
In the Journals

Early SCID identification improved survival after HSCT

July 30, 2014
Patients with severe combined immunodeficiency demonstrated improved survival when they underwent hematopoietic-cell transplantation at a younger…
Institution Notes

Cancer center designated as Blue Distinction Center in bone marrow transplant

July 21, 2014
BlueCross BlueShield of Western New York recently redesignated Roswell Park Cancer Institute as a Blue Distinction Center for delivering quality…
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