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Donor leukocyte telomere length linked to transplantation outcomes in aplastic anemia

February 10, 2015

Longer donor leukocyte telomere length was associated with improved survival in patients with severe aplastic anemia who underwent allogeneic hematopoietic stem cell transplantation, according to study results.

Shahinaz M. Gadalla, MD, PhD, of the clinical genetics branch at the NCI, and colleagues evaluated data from 330 patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) with unrelated donors between 1989 and 2007. The majority (71%) of patients had acquired severe aplastic anemia, 26% had Fanconi anemia and 3% had Diamond-Blackfan anemia.

Christopher Röllig, MD In the Journals

Allogeneic HSCT prolonged RFS in NPM1-mutated AML

February 4, 2015
Allogeneic hematopoietic stem cell transplantation was associated with significantly improved RFS in patients with acute myeloid leukemia who harbored…
In the JournalsPerspective

Biomarkers predicted severity of GVHD after allogeneic HSCT

January 29, 2015
A prognostic score based on the concentration of biomarkers guided risk-adapted therapy at the onset of graft-versus-host disease following allogeneic hematopoietic stem…
In the Journals

Improved surveillance, prophylaxis suggested for CMV in pediatric bone marrow transplantation

January 21, 2015
Improved surveillance and pre-emptive therapies may be required to better manage late-onset cytomegalovirus infections among pediatric bone marrow transplant…
CME
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Targeted Therapy and Immunotherapy in the Management of Metastatic Melanoma: 2014 Updates

This activity is supported by an educational grant from Merck & Co., Inc.

Melanoma remains a challenging condition for clinicians. An array of targeted therapies and immunotherapy are in…
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CME CNE
Low Risk AAMDS

Treatment Decision-Making through the Spectrum of MDS:
Case 1 Low Risk MDS

An educational presentation from Aplastic Anemia & MDS International Foundation.

MDS is a difficult disease to diagnose and treat. Frequently it is challenging for healthcare providers to explain MDS…
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In the Journals

Donor leukocyte telomere length linked to transplantation outcomes in aplastic anemia

February 10, 2015
Longer donor leukocyte telomere length was associated with improved survival in patients with severe aplastic anemia who underwent allogeneic…
Christopher Röllig, MD In the Journals

Allogeneic HSCT prolonged RFS in NPM1-mutated AML

February 4, 2015
Allogeneic hematopoietic stem cell transplantation was associated with significantly improved RFS in patients with acute myeloid leukemia who…
In the JournalsPerspective

Biomarkers predicted severity of GVHD after allogeneic HSCT

January 29, 2015
A prognostic score based on the concentration of biomarkers guided risk-adapted therapy at the onset of graft-versus-host disease following…
In the Journals

Improved surveillance, prophylaxis suggested for CMV in pediatric bone marrow transplantation

January 21, 2015
Improved surveillance and pre-emptive therapies may be required to better manage late-onset cytomegalovirus infections among pediatric bone marrow…
In the Journals

Stem cell transplant effectively treated pediatric patient with severe metabolic disorder

January 16, 2015
Allogeneic hematopoietic stem cell transplant appears to be safe and effective for pediatric patients with mevalonate kinase deficiency who respond…
In the Journals

ST2 levels predicted acute GVHD, mortality after double-unit cord blood transplantation

December 19, 2014
High levels of the biomarker suppressor of tumorigenicity 2 at 28 days post-cord blood transplantation independently predicted acute…
In the Journals

Current smoking linked to invasive fusariosis in patients with acute myeloid leukemia

December 10, 2014
Researchers at the Universidade Federal do Rio de Janeiro in Brazil determined that active smoking was associated with invasive fusariosis among…
Meeting News CoveragePerspective

CD146 may serve as novel target to treat gastrointestinal GVHD

December 8, 2014
SAN FRANCISCO — A population of CD146+ and chemokine receptor 5-positive, Th17-prone T cells may serve as an early marker for patients who are…
Meeting News CoveragePerspective

Autologous HSCT evolves as standard of care for HIV-associated lymphoma

December 6, 2014
SAN FRANCISCO — Autologous hematopoietic stem cell transplantation conferred favorable outcomes in patients with HIV-associated…
Brentuximab vedotin stalled Hodgkin’s lymphoma progression after autologous HSCT Meeting News CoveragePerspective

Brentuximab vedotin stalled Hodgkin’s lymphoma progression after autologous HSCT

December 6, 2014
SAN FRANCISCO — Brentuximab vedotin safely and effectively stalled disease progression in patients with Hodgkin’s lymphoma when…
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