Top Story

Somatic mutations in myelodysplastic syndrome linked to shorter survival after HSCT

August 18, 2014

Patients with myelodysplastic syndrome who harbored TP53, TET2 or DNMT3A mutations demonstrated significantly shorter OS after allogeneic hematopoietic stem-cell transplantation, according to study results.

Rafael Bejar, MD, PhD, assistant professor of medicine at University of California, San Diego, and colleagues evaluated tumor samples from 87 patients (median age, 58 years) before they underwent HSCT. Researchers used massively parallel sequencing to evaluate the samples for 40 genes commonly mutated in myelodysplastic syndrome.

figure In the Journals

Sirolimus failed to reduce GVHD rates after HSCT

August 13, 2014
The incidence of graft-versus-host disease after related donor allogeneic hematopoietic stem cell transplantation was similar among patients who received tacrolimus with…
In the Journals

Early SCID identification improved survival after HSCT

July 30, 2014
Patients with severe combined immunodeficiency demonstrated improved survival when they underwent hematopoietic-cell transplantation at a younger age, before the onset…
Institution Notes

Cancer center designated as Blue Distinction Center in bone marrow transplant

July 21, 2014
BlueCross BlueShield of Western New York recently redesignated Roswell Park Cancer Institute as a Blue Distinction Center for delivering quality transplant care as part…

MPN Updates

This electronic newsletter is sponsored by Incyte Corp. through a third-party independent grant.

1/8/2014
As the standards of care for patients with myeloproliferative neoplasms (MPNs) continue to evolve, physicians must stay…
More »

Filter By:

In the Journals

Somatic mutations in myelodysplastic syndrome linked to shorter survival after HSCT

August 18, 2014
Patients with myelodysplastic syndrome who harbored TP53, TET2 or DNMT3A mutations demonstrated significantly shorter OS after allogeneic…
figure In the Journals

Sirolimus failed to reduce GVHD rates after HSCT

August 13, 2014
The incidence of graft-versus-host disease after related donor allogeneic hematopoietic stem cell transplantation was similar among patients who…
In the Journals

Early SCID identification improved survival after HSCT

July 30, 2014
Patients with severe combined immunodeficiency demonstrated improved survival when they underwent hematopoietic-cell transplantation at a younger…
Institution Notes

Cancer center designated as Blue Distinction Center in bone marrow transplant

July 21, 2014
BlueCross BlueShield of Western New York recently redesignated Roswell Park Cancer Institute as a Blue Distinction Center for delivering quality…
In the Journals Perspective

High-dose melphalan plus salvage ASCT improved outcomes in relapsed myeloma

July 17, 2014
High-dose melphalan chemotherapy plus salvage autologous stem cell transplantation in patients with relapsed multiple myeloma significantly prolonged…

Non-myeloablative allogeneic HSCT shows promise for adults with sickle cell disease

July 1, 2014
Adults with sickle cell phenotype achieved a high rate of stable mixed-donor chimerism and disease reversal after they underwent non-myeloablative…

Top 8 lessons learned at ASCO 2014

June 25, 2014
The theme of this year’s ASCO Annual Meeting, “Science and Society,” emphasized patient-centered focus — looking at the full…
In the Journals Perspective

Study identifies link between gut bacteria, post-SCT survival

June 25, 2014
The variety of bacteria found in the gastrointestinal tracts of patients who undergo allogeneic stem cell transplant may help predict post-transplant…
Meeting News Coverage Video

CD19-targeted T-cells show potential in B-ALL, allogeneic stem cell transplantation

June 19, 2014
CHICAGO — Eunice Wang, MD, associate professor in the department of medicine at Roswell Park Cancer Institute, offers her perspective on the…
In the Journals

HSCT from CMV-positive donors decreased survival in CMV-negative patients

June 2, 2014
Survival was decreased for cytomegalovirus-seronegative patients who received a hematopoietic allogeneic stem cell transplant, or HSCT, from an…
More Headlines »