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Higher CD8 T-cell dose from younger donors improves allogeneic HSCT outcomes

Higher CD8 T-cell dose from younger donors improves allogeneic HSCT outcomes
July 2, 2015

A higher graft CD8 dose from younger donors — even if they are not related to the patient — predicted improved survival in patients with hematologic malignancies undergoing reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation, according to study results.

Further, a blood test to measure the T lymphocyte count in donors may help identify the best donor match for patients undergoing hematopoietic stem cell transplant (HSCT), the researchers found.

In the Journals

HSCT improves survival for older patients with multiple myeloma

June 30, 2015
Hematopoietic stem cell transplantation improved OS for elderly patients with multiple myeloma in the real-world setting, according to results of a SEER…
In the Journals

Graft-versus-host disease causes enteric bacterial BSI in children after HCT

May 19, 2015
Acute gastrointestinal graft-versus-host disease is likely to cause greater enteric bacterial bloodstream infection density in children who have had allogeneic…
In the Journals

Gene therapy effectively treats complications of Wiskott-Aldrich syndrome in children

May 18, 2015
In a small cohort of children and adolescents with Wiskott-Aldrich syndrome, autologous hematopoietic stem cell gene therapy led to clinical improvements in symptoms of…
CME
Hematology Oncology Case Consults

The Patient with Chronic Lymphocytic Leukemia

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of patients with chronic lymphocytic leukemia.
More »
Meeting News Coverage Video
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CD19-targeted T-cells show potential in B-ALL, allogeneic stem cell transplantation

June 19, 2014
CHICAGO — Eunice Wang, MD, associate professor in the department of medicine at Roswell Park Cancer Institute…
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CME
Hematology Oncology Case Consults

The Patient with Melanoma

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of patients with melanoma.
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Ran Reshef, MD In the Journals

Higher CD8 T-cell dose from younger donors improves allogeneic HSCT outcomes

July 2, 2015
A higher graft CD8 dose from younger donors — even if they are not related to the patient — predicted improved survival in patients with…
In the Journals

HSCT improves survival for older patients with multiple myeloma

June 30, 2015
Hematopoietic stem cell transplantation improved OS for elderly patients with multiple myeloma in the real-world setting, according to results of a…
In the Journals

Graft-versus-host disease causes enteric bacterial BSI in children after HCT

May 19, 2015
Acute gastrointestinal graft-versus-host disease is likely to cause greater enteric bacterial bloodstream infection density in children who have…
In the Journals

Gene therapy effectively treats complications of Wiskott-Aldrich syndrome in children

May 18, 2015
In a small cohort of children and adolescents with Wiskott-Aldrich syndrome, autologous hematopoietic stem cell gene therapy led to clinical…
Stephen D. Nimer, MD Industry News

Cancer center director receives award from Bone Marrow Foundation

May 17, 2015
Stephen D. Nimer, MD, director of Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, received the Dr. E…
VIDEO: T-cell immunotherapy may induce durable remissions in post-HSCT lymphoproliferative disorder Meeting News CoverageVideo

VIDEO: T-cell immunotherapy may induce durable remissions in post-HSCT lymphoproliferative disorder

April 27, 2015
Richard J. O’Reilly, MD, chairman of the department of pediatrics at Memorial Sloan Kettering Cancer Center, provides an overview of trials…
Hemant Murthy, MD In PracticePublication Exclusive

State of the science: High-priority transplant trials for nonmalignant disease

HemOnc Today, April 25, 2015
Hemant Murthy, MD; William Wood, MD
Last June, we launched a series of columns in HemOnc Today intended to discuss high-priority proposals that emerged from the 2014 Blood and Marrow…
In the Journals

HSCT associated with increased risk for fractures

April 24, 2015
Patients who underwent hematopoietic stem cell transplantation had a considerably higher incidence of fractures compared with the general population…
Meeting News Coverage

HBV reactivation prevalent after hematopoietic stem cell transplant

April 24, 2015
VIENNA — Hepatitis B virus infection reactivation was prevalent in treatment-naive patients undergoing hematopoietic stem cell transplantation…
Richard J. O’Reilly, MD Meeting News CoveragePerspective

T-cell immunotherapy appears effective in post-HSCT lymphoproliferative disorder

April 20, 2015
PHILADELPHIA — A new type of T cell-based immunotherapy induced response in a majority of patients with Epstein-Barr virus-associated…
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