t(14;18) translocation predicted follicular lymphoma development

  • April 23, 2014

High t(14;18) frequency in the blood of healthy individuals appears to be the first predictive biomarker for follicular lymphoma, and it is apparent several years prior to diagnosis, according to study results.

“The identification of committed t(14;18) cells at high frequency in participants developing follicular lymphoma provides a unique opportunity to unravel key genomic alterations paving the progression from pre-follicular lymphoma to follicular lymphoma through genome-wide approaches,” the researchers wrote. “This might contribute to the design of noncytotoxic targeted therapy in the near future, which may be beneficial in well-defined, less-advanced/refractory forms of the disease.”

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