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Tamoxifen reduces density, improves survival in ER-positive breast cancer

March 6, 2015

Women with ER-positive breast cancer who experience a decline in mammographic density after the initiation of tamoxifen may have improved prognosis regardless of age, according to study findings.

“Women with higher breast density before treatment experienced the greatest reductions in risk of death,” Gretchen L. Gierach, PhD, MPH, an investigator in the hormonal and reproductive epidemiology branch of the NCI, told HemOnc Today. “Our results, in conjunction with the literature, suggest that reductions in mammographic density may be an early indicator of the long-term effectiveness of tamoxifen and could inform decisions on continued tamoxifen therapy or a change clinical management.”

Pedram Gerami, MD In the Journals

Gene expression profiling, SLNB improved prediction of metastasis risk in patients with melanoma

March 6, 2015
A gene expression profile test improved identification of the metastasis risk in patients with melanoma who underwent sentinel lymph node biopsy, according to recently…
In the Journals

Time-dependent treatment may lead to better CML outcomes

March 6, 2015
Switching from imatinib to nilotinib at the right time may be a beneficial treatment strategy for some patients with chronic phase chronic myeloid leukemia, according to…

SARAH Study completes enrollment for HCC trial, results expected in 2016

March 6, 2015
The SARAH Study, a large French study of patients with advanced, inoperable hepatocellular carcinoma, has completed enrollment with more than 400 patients and expects…
Maura M. Zylla, MD In the Journals

Intracardiac thrombi rates lower with dabigatran, rivaroxaban, compared with phenprocoumon

March 6, 2015
The prevalence of intracardiac thrombi was lower in high-risk patients with atrial fibrillation and flutter treated with direct oral anticoagulants compared with…
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CME CNE
Stem Cell Transplant for AAMDS

Treatment Decision-Making through the Spectrum of MDS:
Case 3 Stem Cell Transplant for MDS

An educational presentation from Aplastic Anemia & MDS International Foundation.

MDS is a difficult disease to diagnose and treat. Frequently it is challenging for healthcare providers to explain to…
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Video
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MET targeting, PD-L1/PD-1 inhibition highlight recent developments in genitourinary oncology

February 11, 2015
Derek Raghavan, MD, PhD, FACP, FRACP, FASCO, president of Levine Cancer Institute at Carolinas HealthCare System and…
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CME CNE
High Risk AAMDS

Treatment Decision-Making through the Spectrum of MDS:
Case 2 High Risk MDS

An educational presentation from Aplastic Anemia & MDS International Foundation.

MDS is a difficult disease to diagnose and treat. Frequently it is challenging for healthcare providers to explain to…
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