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Age-related clonal hematopoiesis increased risk for hematologic malignancies

November 26, 2014

Somatic mutations that led to clonal outgrowth of hematopoietic cells occurred more frequently in older patients and were associated with an increased risk for hematologic malignancies, according to results of two studies published in The New England Journal of Medicine.

The first analysis — conducted by Siddhartha Jaiswal, MD, PhD, clinical fellow in pathology at Massachusetts General Hospital, and colleagues — included 17,182 adults who were unselected for hematologic phenotypes (median age, 58 years). A majority of these participants (n=15,801) were enrolled in type 2 diabetes association studies, and 1,381 were enrolled in the Jackson Heart Study.

In the Journals

Higher copayments linked to therapy nonadherence, discontinuation among women with breast cancer

November 26, 2014
Women with early-stage breast cancer who used generic aromatase inhibitors appeared more likely to continue and adhere to their hormone therapy regimens than women who…
Peter J. Mazzone, MD, FCCP Meeting News Coverage

Serum metabolites may serve as biomarker for early lung cancer detection

November 26, 2014
Serum metabolite profiles significantly differed between patients with stage I to III non–small cell lung cancer and at-risk adults without lung cancer, a finding…
In the Journals

Total-body photography may reduce melanoma worry in patients with atypical mole syndrome

November 26, 2014
The use of total-body digital photography may reduce concerns about melanoma development among patients with atypical mole syndrome, according to study results.Molly S
In the Journals

Researchers identify factors associated with hypocalcemia after thyroidectomy

November 25, 2014
A low postoperative intact parathyroid hormone level, female gender and presence of malignant neoplasm all independently predicted hypocalcemia after total…
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CME
Activity cover

Targeted Therapy and Immunotherapy in the Management of Metastatic Melanoma: 2014 Updates

This activity is supported by an educational grant from Merck & Co., Inc.

Melanoma remains a challenging condition for clinicians. An array of targeted therapies and immunotherapy are in…
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Meeting News Coverage Video
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Risk stratification guidelines help determine treatment for thyroid cancer

November 11, 2014
Fabian Pitoia, MD,  head of the thyroid section of the division of endocrinology at the Hospital de Clinicas of…
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CME CNE
High Risk AAMDS

Treatment Decision-Making through the Spectrum of MDS: Case 2 High Risk MDS

An educational presentation from Aplastic Anemia & MDS International Foundation.

MDS is a difficult disease to diagnose and treat. Frequently it is challenging for healthcare providers to explain to…
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