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BRCA1 mutations linked to increased risk for serous, serous-like endometrial carcinoma

<i>BRCA1</i> mutations linked to increased risk for serous, serous-like endometrial carcinoma
June 30, 2016

Women who harbored a BRCA1 mutation had increased risk for serous and serous-like endometrial carcinoma following risk-reducing salpingo-oophorectomy, according to the results of a prospective cohort study.

Although risk-reducing salpingo-oophorectomy is standard for women who harbor BRCA mutations, the role of concomitant hysterectomy is controversial because the risk for uterine cancer in this cohort had been unclear. Some studies had suggested that the risk for uterine corpus cancer in these women was linked to tamoxifen citrate use.

Cover StoryFrom OT Europe

Advanced imaging and genomics may foster better musculoskeletal tumor diagnoses

Orthopaedics Today Europe, June 2016
Recent research has led to meaningful advances in the diagnosis of primary musculoskeletal tumors. From information about tumor-specific phenotypes to improved imaging…
In the Journals

Timing of adjuvant chemotherapy initiation does not impact pancreatic cancer outcomes

June 30, 2016
Patients with pancreatic cancer who initiated chemotherapy more than 12 weeks following resection appeared to experience similar survival as patients who initiated…
In the Journals

Dose-sparing schedule may prolong response with IV romidepsin for cutaneous T-cell lymphoma

June 30, 2016
Switching from a standard-dosing schedule to a reduced-dose schedule may prolong response in select patients with cutaneous T-cell lymphoma treated with romidepsin…
In the Journals

Hyperthyroidism linked to lower recurrent VTE risk among elderly patients

June 29, 2016
Older patients with subclinical hyperthyroidism appeared at lower risk for recurrent venous thromboembolism, according to the results of a prospective cohort study…
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Updates from Vienna 2015 – Highlights in Hematologic Malignancies

This activity is supported by an educational grant from Genentech, Inc.

The management of patients with hematologic malignancies—from diagnosis to treatment decisions—can represent a…
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At Issue

VIDEO: Toxicities related to immune therapies ‘unpredictable’ but ‘manageable’

June 23, 2016
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2016 ASCO Annual Meeting

2016 ASCO Annual Meeting

CME Video

Optimizing the Management of Metastatic Melanoma: Clinical Insights for Selecting First-line Therapy

This activity is supported by an independent educational grant from Merck & Co., Inc.

The incidence of melanoma is continuing to increase worldwide. In recent years, the treatment landscape for this…
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