An ileal bile acid transporter accelerated colonic transit and loosened stool consistency in women with functional constipation, according to a study.
In the double-blind, placebo-controlled study, 36 women were given 15 mg or 20 mg of A3309, a small molecule inhibitor of the ileal bile acid transporter, once daily for 2 weeks.
Investigators observed accelerated overall colonic transit with 20 mg A3309 compared to placebo (P=.059). Colonic transit at 48 hours was accelerated with both dosages of A3309 (P<.001).
Patients reported greater ease of stool passage and reduced straining, the study authors said. Lower abdominal cramping or pain was the most common side effect reported.
Disclosure: Graffner is an employee of Albireo. Camilleri serves as a member of an advisory board of Albireo with compensation to his employer, Mayo Clinic, only and not to him.