Gastroenterology

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Remimazolam provides adequate sedation during colonoscopy

April 29, 2016

Remimazolam provided adequate sedation in patients undergoing colonoscopy with a superior success rate compared with midazolam, according to the results of a phase 2b trial.

“Remimazolam is a benzodiazepine developed to provide sedative effects with a short half-life (terminal elimination half-life 0.75 hours compared with 4.29 hours for midazolam) translating into a quick onset and offset of effect,” the researchers wrote. “This ester-based drug is rapidly hydrolyzed in the body by tissue esterases to an inactive carboxylic acid metabolite. To date, three clinical trials for procedural sedation have been completed and reported, and this manuscript describes the fourth.”

FITZROY: Crohn’s patients maintain clinical response with filgotinib

April 29, 2016
Additional data from the phase 2 FITZROY study showed patients with Crohn’s disease experienced continued clinical response with filgotinib through 20 weeks…

Eiger licenses lambda to investigate potential therapy for hepatitis delta

April 29, 2016
Eiger BioPharmaceuticals Inc. announced it licensed pegylated interferon lambda-1a to Bristol-Myers Squibb to investigate the efficacy and safety of the drug as a…
In the Journals

ACP: Physicians can help tackle public health threat of climate change

April 29, 2016
Climate change poses a significant threat to public health and needs to be addressed by drastic actions in part by physicians and the health care community, according to…
In the Journals

CT colonography comparable to flexible sigmoidoscopy for CRC screening

April 29, 2016
CT colonography performed with a comparable detection rate to flexible sigmoidoscopy as a screening test for colorectal cancer in two randomized clinical trials in…
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CME

The Patient with Postprandial Right Upper Quadrant Abdominal Pain

No commercial support for this activity.

Enhanced imaging technology associated with increased utilization has increased the recognition of biliary tract…
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Video
Meeting News Coverage

Lower dose of Ocaliva may reduce pruritus occurrence in PBC

April 19, 2016
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Highlights from International Liver Congress

Highlights from International Liver Congress

CME Video

Advances in Ulcerative Colitis Management: Targeting Inflammation to Achieve Remission Across the Disease Spectrum

This activity is supported by an educational grant from Salix, A Dvision of Valeant Pharmaceuticals North America, LLC.

Although ulcerative colitis (UC) is globally one of the most common inflammatory bowel diseases, many patients continue…
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