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Long-term paracetamol use may increase risk for adverse events

March 3, 2015

Researchers reported a dose-response association between paracetamol and adverse events similar to those observed with NSAIDs, including mortality, CV, gastrointestinal and renal adverse events, according to results of a systematic literature review.

“Although the studies we included contained somewhat imperfect data — as long-term observational studies usually do, with all sorts of biases that cannot be easily detected, such as use of over-the-counter medicines — people taking paracetamol long-term, especially at higher doses, were at risk for problems that are usually not thought of as side effects of paracetamol,” Philip Conaghan, PhD, FRACP, FRCP, professor of musculoskeletal medicine at the University of Leeds, told Cardiology Today.

In the Journals

Expert discusses ASCO's policy statement on obesity–cancer link

March 3, 2015
Nearly 500,000 Americans are projected to be diagnosed with obesity-associated cancers annually by 2030, according to an ASCO press release. As previously reported in…

AGA announces $2.25 million endowment for neuroenteric disease research

March 3, 2015
The American Gastroenterological Association Research Foundation has announced receipt of a philanthropic donation that will fund an award to advance research in…
Lim receives 2015 Harry M. Vars award for liver disease study

Lim receives 2015 Harry M. Vars award for liver disease study

March 2, 2015
The American Society for Parenteral and Enteral Nutrition, or ASPEN, named David Lim, MD, CM, of the University of Alberta, the recipient of the 2015 Harry M. Vars…
Jennifer Dotson, MD In the Journals

Racial disparities exist among children with Crohn's disease

March 2, 2015
Disparities in hospital readmissions, complications and procedures in pediatric Crohn’s disease patients are related to race, according to data from a recent…
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CME
Pediatric Metabolic Liver Disorders: Diagnostic Challenges via Case Choice

Pediatric Metabolic Liver Disorders: Diagnostic Challenges via Case Choice

This activity is supported by an educational grant from Synageva Biopharma.

Genetic abnormalities affecting the synthesis or catabolism of metabolic enzymes can lead to the development of serious…
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Prior bowel surgery predicted less durable long-term remission in Crohn's disease patients

December 12, 2014
ORLANDO, Fla. — Gary R. Lichtenstein, MD, FACG, AGAF, from the University of Pennsylvania, discusses…
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CME
HCV Council 2014 Revisited at AASLD - Critical Appraisal of Data: Recommendations for Clinical Practice in a Rapidly Evolving Therapeutic Landscape

HCV Council 2014 Revisited at AASLD - Critical Appraisal of Data: Recommendations for Clinical Practice in a Rapidly Evolving Therapeutic Landscape

This activity is supported by an educational grant from AbbVie Inc., Gilead Sciences, Inc., and Janssen Therapeutics, Division of Janssen Products, LP.

Chronic hepatitis C virus (HCV) infection is a leading cause of cirrhosis, end-stage liver disease, hepatocellular…
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