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Serum testosterone levels vary throughout day following transdermal application

July 6, 2015

Dose adjustments of AndroGel for older men with hypogonadism should not be based on a single, post-application serum testosterone measurement, as serum concentrations can vary throughout the day, according to research in The Journal of Clinical Endocrinology & Metabolism.

In a randomized double blind, placebo-controlled trial with older men assigned either AndroGel 1% (transdermal testosterone gel, AbbVie) a matched placebo gel to treat symptoms of hypogonadism, researchers found a wide variation in serum testosterone (T) levels among participants; serum levels collected 2 hours after T gel application in two separate, ambulatory visits did not reflect serum T levels collected at multiple points throughout the day during a third, inpatient visit.

In the Journals

Increasing aromatase activity preserves estrogen levels in older premenopausal women

July 6, 2015
Older premenopausal women maintain estrogen levels despite declining ovarian function because of an increase in ovarian aromatase activity, according to research in The

AACE to examine role of SGLT2 inhibitors in diabetic ketoacidosis

July 5, 2015
The American Association of Clinical Endocrinologists will host a conference this fall to explore the incidence of diabetic ketoacidosis in patients treated with SGLT2…
In the Journals

Financial markets may be destabilized by traders’ hormone levels

July 4, 2015
Testosterone and cortisol levels may cause adults on the trading room floor to take more risks that may cause destabilization in financial markets, according to…
In the Journals

Telemedicine, outpatient visits offer similar results for adults with diabetic foot ulcers

July 3, 2015
Adults with diabetic foot ulcers who consulted with clinicians by telephone or email experienced similar outcomes when compared with adults with diabetic foot ulcers…
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CME
Assessing Cornerstones for Successful Weight Loss

Assessing Cornerstones for Successful Weight Loss: Building a Foundation that Really Works

This activity is supported by an educational grant from Takeda Pharmaceuticals International, Inc., US Region and Orexigen Therapeutics, Inc.

Obesity has increased dramatically in the past 2 decades and is now considered a health care epidemic in the United…
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Meeting News Coverage Video
VIDEO: Joint position statement addresses diabetes self-management education

VIDEO: Joint position statement addresses diabetes self-management education

June 12, 2015
BOSTON — Linda M. Siminerio, RN, PhD, CDE, of the University of Pittsburgh, discusses a newly released joint…
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Real-world Use of Anti-VEGF Therapy

Real-world Use of Anti-VEGF Therapy

This activity is supported by an educational grant from Genentech, Inc.

Anti-VEGF is well established as first-line therapy for the treatment of diabetic macular edema (DME) and age-related…
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