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High-fat diet does not affect insulin sensitivity in women with obesity

November 30, 2015

In healthy premenopausal black and white women with overweight and obesity, consumption of a short-term, eucaloric, high-fat diet does not appear to yield a decrease in peripheral insulin sensitivity compared with a low-fat diet, according to recent findings.

Jeanine B. Albu, MD, of St. Luke’s Roosevelt Hospital Center and Icahn School of Medicine at Mount Sinai in New York, and colleagues evaluated 23 healthy black and white women aged 25 to 45 years with overweight or obesity (BMI, 25-40 kg/m2) recruited from St. Luke’s Roosevelt Hospital Center. For 7 consecutive days, participants consumed one of two diets: a low-fat (30% fat, 50% carbohydrate and 20% protein) or a high-fat (50% fat, 30% carbohydrate and 20% protein) diet. On day 8, insulin sensitivity and substrate utilization were evaluated before and during a euglycemic hyperinsulinemic clamp. A washout period of at least 2 weeks was implemented between dietary regimens, and all measurements were taken during the follicular phase of the menstrual cycle.

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