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Early data shows potential drug for metabolic liver disease well tolerated

May 26, 2015

Phase 1 clinical data showed DUR-928, a small-molecule, new chemical entity that could potentially treat nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, was well tolerated in healthy volunteers, according to a press release from the manufacturer.

In the randomized, multiple-ascending-dose study, 20 healthy volunteers received single doses of DUR-928 daily for 5 days. The patients were divided into two consecutive 10-volunteer cohorts, with the first 10 volunteers receiving DUR-928 at a lower dose and the second at a higher dose, according to the release.

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