February 12, 2016
Exposure during middle age to atrial natriuretic peptide within the high normal range appears to be associated with a reduced risk for insulin resistance after 16.5 years of follow-up.
Amra Jujić, PhD, of the department of cardiology at Skane University Hospital in Sweden, and colleagues evaluated data from the Malmö Diet and Cancer Study cardiovascular cohort on 2,243 patients without diabetes. An immunoluminometric sandwich assay was used to measure midregional pro-atrial natriuretic peptide (MR-proANP). At 16.5 years of follow-up, an oral glucose tolerance test was used to measure glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1, insulin, glucose and glucagon.