September 2, 2015
Cross-sectional analysis of the Alzheimer’s Disease Neuroimaging Initiative study cohort suggests type 2 diabetes may encourage neurodegeneration independent of Alzheimer’s disease dementia, and may be driven by tau phosphorylation.
“Type 2 diabetes mellitus is associated with a nearly 2-fold increased incident risk of dementia and [Alzheimer’s] disease dementia,” Chris Moran, MBBCh, of the Stroke and Aging Research Group at Monash University in Melbourne, Australia, and colleagues wrote. “Recently, we demonstrated that the association between [type 2 diabetes] and cognitive impairment in older age may primarily be driven by brain atrophy rather than cerebrovascular brain lesions, and that this atrophy occurs in cortical regions similar to those affected in [Alzheimer’s disease] dementia. However, there are limited data available from in vivo studies to determine whether [type 2 diabetes] contributes to the accumulation of [Alzheimer’s disease] pathology.”