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Lanreotide shows promise in patients with pancreatic neuroendocrine tumors

January 28, 2015

Lanreotide demonstrated antitumor activity with a manageable safety profile in patients with pancreatic neuroendocrine tumors, according to a subgroup analysis of the CLARINET study presented at the Gastrointestinal Cancers Symposium.

The randomized, double blind CLARINET study included patients with metastatic grade 1 or grade 2 (Ki-67 <10%) non-functioning enteropancreatic neuroendocrine tumors. Patients underwent first-line treatment with 120 mg lanreotide (Somatuline Depot, Ipsen), a somatostatin analog, or placebo every 4 weeks for 96 weeks. Lanreotide was administered by deep subcutaneous injection.

In the Journals

Low-dose HT similar to standard dose, placebo for some CV effects

January 27, 2015
In postmenopausal women undergoing hormone therapy, a low-dose regimen does not appear to differ from the standard dose or placebo in its effects on weight, BMI, blood…
In the Journals

Fast-food labels with caloric, physical activity equivalents encouraged lower-calorie choices

January 27, 2015
Food menu labels that include caloric content may lead to parents ordering fast-food meals with a lower calorie count, and labels that include physical activity…
In the Journals

Leisure-time physical activity reduced CV risk in CAD patients with and without diabetes

January 27, 2015
In patients with coronary artery disease, whether they had type 2 diabetes or not, routine leisure-time physical activity was inversely associated with short-term…
Yang Lu In the Journals

Peer mentoring may improve diabetes management among adolescents

January 27, 2015
Sharing important diabetes management skills and experiences through peer mentoring may help adolescents and young adults with type 1 diabetes control their disease…
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CME
Acromegaly: Challenges in Diagnosis - Part 2 of 5

Acromegaly: Pathophysiology, Signs, Symptoms, and Complications - Part 1 of 5

This activity is supported by an educational grant from Genentech.

An understanding of the pathophysiological mechanisms of acromegaly is important to its various complications as well…
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Meeting News Coverage Video
Hatipoglu th

Autologous islet cell transplantation effective for chronic pancreatitis

December 3, 2014
In this video exclusive, Betul Hatipoglu, MD, clinical associate professor of medicine of the Endocrinology &…
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CME
Experts Take: Dialogue on HTG

Experts’ Take: Dialogue on Hypertriglyceridemia

This activity is supported by an independent educational grant from Amarin Pharma Inc.

Lead by genetic studies, recent data describe a causal role of triglycerides (TG) in the formation of atherosclerosis…
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