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Increasing aromatase activity preserves estrogen levels in older premenopausal women

July 6, 2015

Older premenopausal women maintain estrogen levels despite declining ovarian function because of an increase in ovarian aromatase activity, according to research in The Journal of Clinical Endocrinology & Metabolism.

Natalie Shaw, MD, MMSc, a clinical and research fellow in the reproductive endocrine unit, department of medicine at Massachusetts General Hospital in Boston, and colleagues analyzed data from 27 white women aged 22 to 45 years with normal BMI and regular menstrual cycles. Within the cohort, 13 women were aged 36 to 45 years (mean age, 40 years) and 14 women were aged 22 to 34 years (mean age, 27 years). Researchers measured granulosa cell aromatase expression and reproductive hormones in follicular fluid aspirates from the dominant follicle and compared hormone levels between the older and younger women. Participants underwent daily blood tests from the first day of menses until the day of follicle aspiration; researchers performed transvaginal ultrasounds every 2 to 3 days from cycle day 7 on to monitor follicle growth.

AACE to examine role of SGLT2 inhibitors in diabetic ketoacidosis

July 5, 2015
The American Association of Clinical Endocrinologists will host a conference this fall to explore the incidence of diabetic ketoacidosis in patients treated with SGLT2…
In the Journals

Financial markets may be destabilized by traders’ hormone levels

July 4, 2015
Testosterone and cortisol levels may cause adults on the trading room floor to take more risks that may cause destabilization in financial markets, according to…
In the Journals

Telemedicine, outpatient visits offer similar results for adults with diabetic foot ulcers

July 3, 2015
Adults with diabetic foot ulcers who consulted with clinicians by telephone or email experienced similar outcomes when compared with adults with diabetic foot ulcers…
In the Journals

Physician urges FDA not to lift restrictions on drug makers’ claims about their products

July 3, 2015
Drug regulations and a governing body to mandate them is a necessity for patients’ safety and health care providers’ peace-of-mind, according to a recently…
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CME
Obesity Consults: Volume 2, Number 4 Obesity and the Cardiovascular System

Obesity Consults: Volume 2, Number 4
Obesity and the Cardiovascular System

This activity is supported by an educational grant from Eisai, Inc. and Vivus, Inc.

Obesity is associated with a wide range of comorbid conditions, including diabetes, hypertension, sleep apnea, and…
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Meeting News Coverage Video
VIDEO: Joint position statement addresses diabetes self-management education

VIDEO: Joint position statement addresses diabetes self-management education

June 12, 2015
BOSTON — Linda M. Siminerio, RN, PhD, CDE, of the University of Pittsburgh, discusses a newly released joint…
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CME
Assessing Cornerstones for Successful Weight Loss

Assessing Cornerstones for Successful Weight Loss: Building a Foundation that Really Works

This activity is supported by an educational grant from Takeda Pharmaceuticals International, Inc., US Region and Orexigen Therapeutics, Inc.

Obesity has increased dramatically in the past 2 decades and is now considered a health care epidemic in the United…
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