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Pioglitazone decreases diabetes, stroke risks in patients with prediabetes, cerebrovascular disease

Pioglitazone decreases diabetes, stroke risks in patients with prediabetes, cerebrovascular disease
July 29, 2016

In insulin-resistant patients with a recent ischemic stroke or transient ischemic attack, pioglitazone was shown to reduce the risk for developing type 2 diabetes and major cardiovascular events, according to an analysis of the IRIS trial.

“Pioglitazone approximately halved the risk of developing diabetes in patients with insulin resistance and cerebrovascular disease,” Silvio Inzucchi, MD, professor of endocrinology and director of the Yale Diabetes Center at Yale School of Medicine, and colleagues wrote. “The absolute diabetes risk was highest in those with [impaired fasting glucose], increased HbA1c, higher [homeostatic model assessment of insulin resistance] (indicating more insulin resistance) and metabolic syndrome, so the preventive effect of pioglitazone was predominately driven by patients in these higher risk categories.”

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