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FDA grants priority review to lenvatinib for advanced thyroid cancer

October 15, 2014

The FDA granted priority review status to lenvatinib mesylate as a treatment for patients with progressive radioactive iodine-refractory differentiated thyroid cancer, according to the drug’s manufacturer.

Lenvatinib (E7080, Eisai) is an oral multiple receptor tyrosine kinase inhibitor that inhibits VEGF receptors 1-3, fibroblast growth factor (FGF) receptors 1-4, platelet-derived growth factor (PDGF) receptor alpha, RET and KIT signaling networks.

figure In the Journals

Thyroid hormone activity during pregnancy altered by endocrine-disrupting chemicals

October 9, 2014
Thyroid activity at the cellular level can be disrupted by polychlorinated biphenyls that infiltrate the placenta during pregnancy, according to recent study findings…
figure In the Journals

Preoperative ultrasound imaging of thyroid cancer essential to preventing additional surgeries

October 8, 2014
The use of comprehensive preoperative imaging enables complete initial surgical removal of thyroid cancer and associated metastases from cervical lymph nodes, according…
In the Journals

Increased levels of PTH during pregnancy linked to dyslipidemia, gestational diabetes

October 7, 2014
An elevated level of parathyroid hormone rather than vitamin D status appears to be associated with dyslipidemia during pregnancy, according to recent findings. The…
CME
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Acromegaly: Pathophysiology, Signs, Symptoms, and Complications - Part 1 of 5

This activity is supported by an educational grant from Genentech.

An understanding of the pathophysiological mechanisms of acromegaly is important to its various complications as well…
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CME
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Acromegaly Cases: Expert Insights into Diagnosis and Emerging Treatment Options – Part 5 of 5

This activity is supported by an educational grant from Genentech.

Acromegaly is a rare chronic disorder that is typically caused by excessive growth hormone secretion, and is…
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FDA News

FDA grants priority review to lenvatinib for advanced thyroid cancer

October 15, 2014
The FDA granted priority review status to lenvatinib mesylate as a treatment for patients with progressive radioactive iodine-refractory…
figure In the Journals

Thyroid hormone activity during pregnancy altered by endocrine-disrupting chemicals

October 9, 2014
Thyroid activity at the cellular level can be disrupted by polychlorinated biphenyls that infiltrate the placenta during pregnancy, according to…
figure In the Journals

Preoperative ultrasound imaging of thyroid cancer essential to preventing additional surgeries

October 8, 2014
The use of comprehensive preoperative imaging enables complete initial surgical removal of thyroid cancer and associated metastases from cervical…
In the Journals

Increased levels of PTH during pregnancy linked to dyslipidemia, gestational diabetes

October 7, 2014
An elevated level of parathyroid hormone rather than vitamin D status appears to be associated with dyslipidemia during pregnancy, according to…
In the Journals

Women treated for hypothyroidism undergoing IVF experience increased TSH levels

October 2, 2014
Serum levels of thyroid stimulating hormone increased significantly during in vitro fertilization among women treated for hypothyroidism, according…
In the Journals

Hypothyroidism before age 60 leads to workplace disability, lower income increases

October 1, 2014
Individuals diagnosed with hypothyroidism before age 60 years have an 89% increased risk of receiving disability pension compared with euthyroid…
Meeting News Coverage

Maternal hypothyroxinemia predicted poor math skills in offspring

September 30, 2014
Children whose mothers experienced hypothyroxinemia at the end of the first pregnancy trimester may have subnormal performance during math tests…
In the Journals

Metformin monotherapy increased risk for low TSH levels

September 24, 2014
Metformin was linked to an increased risk of low thyroid-stimulating hormone levels in patients with hypothyroidism, according to recent study…
figure FDA News Perspective

Advisory Committee recommends approval of PTH therapy for hypoparathyroidism

September 15, 2014
After a debate-filled meeting today, the Endocrinologic and Metabolic Drugs Advisory Committee voted 8 to 5 in favor of approval for recombinant…
In the Journals

Pregnant women with subclinical hypothyroidism more likely to miscarry

September 2, 2014
Among pregnant women at low risk for thyroid dysfunction, the existence of subclinical hypothyroidism, thyroid autoimmunity or both prior to 8…
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