PCOS linked to greater risk for gestational, type 2 diabetes

Joham AE. J Clin Endocrinol Metab. 2013;doi:10.1210/jc.2013-2007.

  • October 14, 2013

Polycystic ovary syndrome was independently linked to a greater risk for gestational diabetes and type 2 diabetes, according to data from the Australian Longitudinal Study on Women’s Health.

Researchers assessed the survey data collected in 2006, one of five survey time points included in the full analysis, to determine the prevalence of dysglycemia and the effect of obesity in women (n=9,145) with and without PCOS.

The prevalence of PCOS was 5.8% among women aged 28 to 33 years (95% CI, 5.3-6.4). In women with PCOS, there was an 11.2% prevalence of gestational diabetes in patients reporting a previous pregnancy and a 5.1% prevalence of type 2 diabetes, researchers wrote. They also reported a 3.8% prevalence of gestational diabetes and 0.3% prevalence of type 2 diabetes in women without PCOS (P<.001).

The likelihood of women developing gestational diabetes (OR=2.1; 95% CI, 1.1-3.9) and type 2 diabetes (OR=8.8; 95% CI, 3.9-20.1) was independently associated with PCOS after adjustments for age, BMI, hypertension, smoking and demographic factors, researchers wrote.

“Our study includes a large cohort of community-based PCOS women, only some of whom required fertility treatment, and therefore is arguably more representative of PCOS women,” the researchers wrote. “Our 2.1-fold higher risk of gestational diabetes in PCOS is slightly lower reflecting the lower risk community-based cohort sampled. Nevertheless, our results confirm the need for proactive screening for gestational diabetes in PCOS.”

Disclosure: The researchers report no relevant financial disclosures.

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