February 9, 2017
In girls with central precocious puberty, elevated leptin levels at diagnosis may be a risk factor for increased BMI z score over the next year, study data show.
Zurita-Cruz, MD, MSc, from the unit for medical research in clinical epidemiology, National Medical Center XXI Century, Mexican Institute of Social Security, and colleagues evaluated 42 girls (median age, 7.2 years; median BMI z score, 1.14; median bone age, 10.5 years) with central precocious puberty; 26 in Tanner breast stage 2 and 16 in breast stage 3. Participants were evaluated at the time of diagnosis (baseline) and 12-month follow-up. Researchers sought to determine whether serum leptin levels are related to BMI z score.