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Reductions in fasting glucose, body weight delay progression of early type 2 diabetes

August 23, 2016

In adults with early type 2 diabetes, reductions in glucose level, driven by reductions in weight, can delay progression of the disease independent of any improvements in beta-cell function, according to a secondary analysis of the Early Diabetes Intervention Program.

“We have demonstrated that in the Early Diabetes Intervention Program, the on-study reduction in fasting glucose was strongly associated with protection from progression,” Kieren Mather, MD, FRCPC, professor of medicine at Indiana University School of Medicine, and colleagues wrote. “This effect was seen after adjustment for the baseline fasting glucose and is therefore not simply an effect of reducing glucose values in those closest to the threshold; rather, it represents the integrated beneficial effect of study interventions.”

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In the Journals Plus

Reductions in fasting glucose, body weight delay progression of early type 2 diabetes

August 23, 2016
In adults with early type 2 diabetes, reductions in glucose level, driven by reductions in weight, can delay progression of the disease independent…

In the Journals

Closed-loop insulin improves glucose control in pregnant women with type 1 diabetes

August 23, 2016
Pregnant women with type 1 diabetes achieved better glucose control with an overnight closed-loop intervention than with sensor-augmented pump…

In the Journals Plus

Canagliflozin may slow renal disease progression

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Canagliflozin, an SGLT2 inhibitor, may be more effective for slowing the progression of renal disease compared with glimepiride, a sulfonylurea, over…

FDA News

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