Pediatric Endocrinology

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GH therapy improves linear growth, adult height in Prader-Willi syndrome

February 23, 2017

Prepubertal and adolescent children with Prader-Willi syndrome treated with recombinant human growth hormone therapy before the onset of puberty saw increased linear growth and adult height over at least 3 years of treatment, according to a worldwide, retrospective cohort study.

“Long-term data of a large group of GH-treated prepubertal children with [Prader-Willi syndrome] have not been reported,” N.E. Bakker, MD, of the Dutch Growth Research Foundation in Rotterdam, the Netherlands, and colleagues wrote. “Results of nationwide studies from the USA, the Netherlands and Switzerland are reassuring, but have the limitation of small patient numbers because [Prader-Willi syndrome] is a rare syndrome. Therefore, the present study was undertaken to evaluate growth during 3 years of GH treatment and adult height data in a large group of children with [Prader-Willi syndrome], by using the Pfizer International Growth Database (KIGS), containing data from 1987 to 2012.”

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Infant antibiotic use associated with obesity at age 2 years

February 21, 2017
Infants exposed to antibiotics in the first 6 months of life were more likely to develop obesity by age 2 years vs. infants not exposed to antibiotics, according to a…
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Hydrolyzed infant formula fails to protect against islet autoimmunity

February 20, 2017
Hydrolyzed cow’s milk-based infant formula did not reduce the risk for developing islet autoimmunity among infants at risk for developing type 1 diabetes, and may…
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Age, insurance status related to hospitalization for children with congenital adrenal hyperplasia

February 17, 2017
Among children with congenital adrenal hyperplasia, those who are younger and those with government insurance may be at increased risk for hospitalization, recent data…
CME

Improving Bone Strength and Reducing Fracture Risk in Osteoporosis

This activity is supported by an educational grant from Merck & Co., Inc.

Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue leading to reduced…
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Practical Lipidology®: Volume 3, Number 1

This activity is supported by an educational grant from Amgen

The reduction of low-density lipoprotein-cholesterol (LDL-C) is recognized as the primary strategy for decreasing…
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In the Journals PlusAbstract Only

The home environment and toddler physical activity: an ecological momentary assessment study

February 26, 2017
AUTHORS: Hager ER, et al.

In the Journals Plus

GH therapy improves linear growth, adult height in Prader-Willi syndrome

February 23, 2017
Prepubertal and adolescent children with Prader-Willi syndrome treated with recombinant human growth hormone therapy before the onset of puberty saw…

In the Journals Plus

Infant antibiotic use associated with obesity at age 2 years

February 21, 2017
Infants exposed to antibiotics in the first 6 months of life were more likely to develop obesity by age 2 years vs. infants not exposed to…

In the Journals Plus

Hydrolyzed infant formula fails to protect against islet autoimmunity

February 20, 2017
Hydrolyzed cow’s milk-based infant formula did not reduce the risk for developing islet autoimmunity among infants at risk for developing type…

In the Journals Plus

Age, insurance status related to hospitalization for children with congenital adrenal hyperplasia

February 17, 2017
Among children with congenital adrenal hyperplasia, those who are younger and those with government insurance may be at increased risk for…

In the Journals Plus

Previous cancer affects future cancer incidence, mortality risk with pediatric GH therapy

February 17, 2017
In patients with previous cancers treated with recombinant human growth hormone therapy as children, researchers observed increased risks for both…

In the Journals Plus

Prenatal adherence to Mediterranean diet may confer cardiometabolic benefit in offspring

February 9, 2017
Pregnant women with a greater adherence to the Mediterranean diet are more likely to have children with lower BMI, blood pressure and leptin levels…

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Ambient air pollution exposure tied to diabetes risk in children with overweight, obesity

February 9, 2017
Prolonged ambient exposure, particularly exposure to nitrogen dioxide and particulate matter with aerodynamic diameter less than 2.5 µm…

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Leptin levels tied to weight gain in central precocious puberty

February 9, 2017
In girls with central precocious puberty, elevated leptin levels at diagnosis may be a risk factor for increased BMI z score over the next year…

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Systematic screening approach may detect endocrine complications in childhood cancer survivors

February 8, 2017
As childhood cancer cure rates have substantially improved, the rate of late-onset endocrine complications among childhood cancer survivors has…

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