May 26, 2017
The frequency of diabetic ketoacidosis precipitating diagnosis of type 1 diabetes in children may be decreased with genetic screening and follow-up for the disease, according to study findings published in Pediatric Diabetes.
Anne M. Hekkala, MD, PhD, of the department of pediatrics at the University Oulu in Finland, and colleagues evaluated children born at Oulu University Hospital since 1995 who were diagnosed with type 1 diabetes when they were younger than 15 years by 2015 (study cohort 1; n = 517) and all children diagnosed with type 1 diabetes younger than 15 years from 2002 to 2014 (study cohort 2; n = 579). Since 1995, newborns in the region have been recruited to be assessed for genetic risk for type 1 diabetes by screening for human leukocyte antigen (HLA) in umbilical cord blood. Researchers sought to determine the frequency of diabetic ketoacidosis (DKA) at diagnosis of type 1 diabetes and whether participation in screening follow-up studies decreased the risk for DKA.