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Serum bicarbonate not independently linked to renal, CV events in diabetic nephropathy

September 16, 2014

Serum bicarbonate was not independently associated with renal or cardiovascular endpoints among a cohort of patients with type 2 diabetes and nephropathy, according to research presented at the 50th European Association for the Study of Diabetes Annual Meeting.

“Chronic kidney disease comes with various consequences and complication,” Elise Schutte, MD, a PhD student of endocrinology/nephrology at the Kidney Center of the University Medical Center Groningen in the Netherlands, said during her presentation. “One of these complications is metabolic acidosis measured as a low serum bicarbonate. Metabolic acidosis, in its turn, also has several complication in the human body. Among those are muscle wasting, bone disease, reduced insulin sensitivity, reduced albumin synthesis and exacerbation of renal failure. Now this last one puts patients at risk for a vicious cycle of CKD, metabolic acidosis and further renal function decline.”

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