Neuroendocrinology

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MEN1 associated with early-onset breast cancer risk in women

MEN1 associated with early-onset breast cancer risk in women
March 24, 2017

Women with multiple endocrine neoplasia type 1 are at greater risk for developing early-onset breast cancer compared with women without the disease, according to findings from a cross-sectional study.

Rachel S. van Leeuwaarde, MD, of the department of endocrine oncology at University Medical Center Utrecht, the Netherlands, and colleagues analyzed data from 138 women with confirmed multiple endocrine neoplasia type 1 (MEN1) or a MEN1 mutation from the Dutch MEN1 cohort, a longitudinal database that includes at least 90% of all Dutch MEN1 patients aged at least 16 years. Women completed either a written or online questionnaire between April 2015 and October 2016 regarding breast cancer-related endocrine risk factors, cancer family history and other known risk factors for breast cancer. Researchers compared the age at breast cancer diagnosis among the MEN1 cohort with the female relatives without MEN1, as well as age of breast cancer onset in the general Dutch population using data from the Netherlands Cancer Registry.

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MEN1 associated with early-onset breast cancer risk in women

March 24, 2017
Women with multiple endocrine neoplasia type 1 are at greater risk for developing early-onset breast cancer compared with women without the disease…

In the Journals Plus

Acromegaly worsens quality of life despite disease control

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Adults with acromegaly report impaired quality of life compared with adults without the disease, and the impairments remain despite long-term disease…

In the Journals Plus

Estrogen exposure may affect pancreatic neuroendocrine tumor size in women with MEN1

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Previous estrogen exposure in women with multiple endocrine neoplasia type 1 may affect size of pancreatic neuroendocrine tumors, but exposure is not…

In the Journals Plus

Acromegaly may increase colon polyp risk

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Adults with acromegaly have an elevated risk for colon polyps, and those who have a higher level of insulin-like growth factor I at diagnosis appear…

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