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Mutations in patients with MEN1 increased risk for malignancy, death

October 29, 2014

Patients with multiple endocrine neoplasia type 1 who have mutations leading to a loss of interaction with certain domain codons may be at higher risk for malignancy and death based on disease process, according to research published in The Journal of Clinical Endocrinology & Metabolism.

With an aggressive course of disease, multiple endocrine neoplasia type 1 (MEN1) patients with a loss of interaction (LOI) with checkpoint suppressor 1 (CHES1) codons (428–610) are more likely to develop pancreatic neuroendocrine neoplasias (pNENs) and die of the disease, researchers found.

In the Journals

Ghrelin paralleled adiposity increase after acromegaly surgery

September 11, 2014
The rise in total ghrelin found to accompany some remaining cardiovascular risk markers and adiposity increase in patients with acromegaly remission after surgery could…
figure In the Journals

Vitamin D deficiency increased dementia, Alzheimer's disease risk

August 7, 2014
Vitamin D deficiency is associated with an increased risk for dementia and Alzheimer’s disease, according to recent study findings published in…
In the Journals

Caffeine may lead to more bothersome vasomotor symptoms

August 1, 2014
The intake of caffeine was positively associated with more bothersome vasomotor symptoms in postmenopausal women, according to research published in Menopause.“In…
CME
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Treatment of Acromegaly: Emerging Options - Part 4 of 5

This activity is supported by an educational grant from Genentech.

Several medical therapies for acromegaly, including somatostatin receptor agonists, dopamine receptor agonists, and a…
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CME
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Acromegaly: Challenges in Diagnosis - Part 2 of 5

This activity is supported by an educational grant from Genentech.

The diagnosis of acromegaly is often not made until 7 to 10 years after symptom onset. Contributing factors include low…
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In the Journals

Mutations in patients with MEN1 increased risk for malignancy, death

October 29, 2014
Patients with multiple endocrine neoplasia type 1 who have mutations leading to a loss of interaction with certain domain codons may be at higher…
In the Journals

Ghrelin paralleled adiposity increase after acromegaly surgery

September 11, 2014
The rise in total ghrelin found to accompany some remaining cardiovascular risk markers and adiposity increase in patients with acromegaly remission…
figure In the Journals

Vitamin D deficiency increased dementia, Alzheimer's disease risk

August 7, 2014
Vitamin D deficiency is associated with an increased risk for dementia and Alzheimer’s disease, according to recent study findings published in…
In the Journals

Caffeine may lead to more bothersome vasomotor symptoms

August 1, 2014
The intake of caffeine was positively associated with more bothersome vasomotor symptoms in postmenopausal women, according to research published in…
In the Journals

Childhood obesity decreased SHBG, lowered puberty age

July 31, 2014
Hormonal disturbances associated with weight gain, along with chronic inflammation, could help explain the declining age of puberty, according to…

Lessons learned from AACE 2014

July 22, 2014
The need for a “hand-in-glove” integration of endocrinology and endocrine surgery was a key lesson learned at this year’s American…
Industry News

U.S. News & World Report announces top hospitals for endocrinology and diabetes care

July 15, 2014
Mayo Clinic and Cleveland Clinic garnered top honors among hospitals for diabetes and endocrinology-related care, as announced today in U.S. News
In the Journals

Neurocognitive deficits with type 1 diabetes could predict outcomes

July 2, 2014
Neurocognitive deficits discovered in children and adolescents within days of receiving a type 1 diabetes diagnosis were associated with disease…
Meeting News Coverage

Hyperglycemia disturbs brain’s functional connectivity, may prompt depression in type 1 diabetes

June 24, 2014
CHICAGO — High levels of the neurotransmitter glutamate observed in patients with type 1 diabetes led one researcher, Nicolas R. Bolo, PhD,
Meeting News Coverage Video

Vlog: Global endocrinology community gathers for ICE/ENDO 2014

June 21, 2014
Ronald Tamler, MD, PhD, MBA, clinical director of the Mount Sinai Diabetes Center and a member of the Endocrine Today editorial board, updated us on…
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