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Novel bioidentical estradiol vaginal capsule shows promise in pilot study

October 21, 2014

WASHINGTON — A novel estradiol vaginal gel cap containing low doses of solubilized bioidentical estradiol improved vaginal cytology and pH in healthy postmenopausal women, according to a presentation at the 25th annual meeting of The North American Menopause Society.

About a half-inch in size, TX-004HR (TherapeuticsMD) capsules of 10 mcg and 25 mcg were safe and well tolerated, with less systemic exposure than with equivalent doses of an existing vaginal estradiol tablet, suggesting another local option for treating menopause-related vulvovaginal atrophy, the researchers said.

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Ospemifene benefited postmenopausal women with vulvar, vaginal atrophy

October 21, 2014
WASHINGTON — In postmenopausal women with vulvar and vaginal atrophy, 
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Weight, libido unchanged with low-dose paroxetine to treat vasomotor symptoms

October 20, 2014
Paroxetine administered in low doses to treat vasomotor symptoms associated with menopause did not yield significant changes in body weight or sexual function, according…
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Lower estradiol, SHBG levels related to ectopic CV fat volumes in women at midlife

October 20, 2014
WASHINGTON — Endogenous sex hormones were associated with ectopic cardiovascular fat volumes in women during varying stages of menopause, according to data…
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