Hormone Therapy

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Oral contraceptives associated with worsening lipid profile in PCOS

May 18, 2017

In women with polycystic ovary syndrome, the use of any oral contraceptive was associated with a rise in triglyceride and total cholesterol levels over time, and oral contraceptives containing third-generation progestins did not offer substantial advantages, according to findings from a systematic review and meta-analysis.

“While in the general population, oral contraceptive use is considered safe with only a modest risk of venous thromboembolism, it is unclear whether the same rule applies to PCOS patients, many of whom present some relative contraindications to the use of [oral contraceptives], [including] being obese, insulin-resistant and/or with altered glucose tolerance or dyslipidemia,” Mina Amiri, a PhD student in the department of reproductive health and midwifery at Shahid Beheshti University of Medical Sciences in Tehran, Iran, and colleagues wrote. “In fact, some studies have raised concern regarding the potential adverse cardiovascular and metabolic effects of [oral contraceptives] in women with PCOS, suggesting worsening of insulin resistance and glucose tolerance, and potential adverse effects on lipid patterns.”

Perspective

USPSTF releases draft recommendation on menopausal hormone therapy

May 16, 2017
The U.S. Preventive Services Task Force has issued a draft recommendation against the use of combined estrogen and progestin for the prevention of chronic conditions in…
FDA News

Long-term safety data needed for investigational estradiol vaginal softgel capsule

May 8, 2017
TherapeuticsMD recently received a Complete Response Letter from the FDA in reply to its New Drug Application for TX-004HR, an investigational applicator-free estradiol…
Meeting News

Testosterone replacement therapy lowers mortality, CV risk in secondary hypogonadism

May 6, 2017
AUSTIN, Texas — Testosterone replacement therapy may lower the risk for myocardial infarction, stroke and all-cause mortality in men with secondary hypogonadism. …
CME

Improving Bone Strength and Reducing Fracture Risk in Osteoporosis

This activity is supported by an educational grant from Merck & Co., Inc.

Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue leading to reduced…
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Meeting News Coverage

Vlog: Global endocrinology community gathers for ICE/ENDO 2014

June 21, 2014
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The Endocrine Society Annual Meeting

The Endocrine Society Annual Meeting

CME

Practical Lipidology®: Volume 3, Number 2

This activity is supported by an educational grant from Amgen

The reduction of low-density lipoprotein-cholesterol (LDL-C) is recognized as the primary strategy for decreasing…
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In the Journals Plus

Oral contraceptives associated with worsening lipid profile in PCOS

May 18, 2017
In women with polycystic ovary syndrome, the use of any oral contraceptive was associated with a rise in triglyceride and total cholesterol levels…

Perspective

USPSTF releases draft recommendation on menopausal hormone therapy

May 16, 2017
The U.S. Preventive Services Task Force has issued a draft recommendation against the use of combined estrogen and progestin for the prevention of…

FDA News

Long-term safety data needed for investigational estradiol vaginal softgel capsule

May 8, 2017
TherapeuticsMD recently received a Complete Response Letter from the FDA in reply to its New Drug Application for TX-004HR, an investigational…

Meeting News

Testosterone replacement therapy lowers mortality, CV risk in secondary hypogonadism

May 6, 2017
AUSTIN, Texas — Testosterone replacement therapy may lower the risk for myocardial infarction, stroke and all-cause mortality in men with…

Meeting News

Doping more prevalent among nonathletes vs. elite competitors

May 3, 2017
AUSTIN, Texas — Contrary to public perception, most androgen abusers are not elite athletes seeking to enhance performance, but instead are…

In the Journals Plus

Hormonal therapy fails to improve BMD in functional hypothalamic amenorrhea

May 2, 2017
Women with functional hypothalamic amenorrhea do not have significantly improved bone health with the use of hormonal therapy vs. placebo and calcium…

In the Journals PlusPerspective

VTE in women may suggest inappropriate prescriptions of combined hormonal contraceptives

April 26, 2017
Women assigned combined hormonal contraceptives who experience a venous thromboembolism may have vascular contraindications suggesting inappropriate…

In the Journals PlusPerspective

Oral contraceptives may lower general well-being in healthy women

April 24, 2017
Swedish women assigned oral contraceptives reported reduced general well-being, but similar burden of depressive symptoms, compared with women…

In the Journals Plus

Estrogen induces pubertal induction in adolescents transitioning from male to female

April 24, 2017
In adolescents transitioning from male to female, estrogen therapy for at least 1 year was effective and safe for inducing puberty, study data…

In the Journals Plus

Subcutaneous testosterone therapy safe, effective in female-to-male transgender patients

April 12, 2017
In female-to-male transgender patients, subcutaneous testosterone therapy was safe and effective and was the preferred route of therapy in patients…

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