Hormone Therapy

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Beloranib safe, effective in adults with Prader-Willi syndrome

January 24, 2016

Adults with Prader-Willi syndrome randomly assigned the MetAP2 inhibitor beloranib for 6 months saw a significant reduction in both body weight and hyperphagia-related behaviors when compared with those assigned placebo, according to phase 3 trial results released by the drug’s developer, Zafgen.

In announcing results from the 6-month randomized, double-blind trial, Thomas Hughes, PhD, CEO of Zafgen, noted the investigational drug is the first to demonstrate a positive impact on both body weight and hyperphagia. The study results follow an FDA complete clinical hold on an investigational new drug application for beloranib, announced in December, due to an imbalance in severe venous thromboembolic events, including two patient deaths.

In the Journals

Compounded HT prescriptions increasing

December 21, 2015
Compounded hormone therapy prescriptions are nearing the number of FDA-approved menopausal hormone therapy prescriptions and are expected to grow, according to the…
In the Journals

Adiposity linked to better response to GH treatment in small for gestational age children

December 9, 2015
In short children born small for gestational age, higher body fat percentage appears to have a positive effect on growth hormone treatment response and glucose…
In the Journals

Progesterone therapy fails to prevent miscarriage

December 7, 2015
A significantly higher rate of live births among women with a history of miscarriages was not found with the use of progesterone supplements, according to recent study…

Beloranib safe, effective in adults with Prader-Willi syndrome

January 24, 2016
Adults with Prader-Willi syndrome randomly assigned the MetAP2 inhibitor beloranib for 6 months saw a significant reduction in both body weight and…
In the Journals

Compounded HT prescriptions increasing

December 21, 2015
Compounded hormone therapy prescriptions are nearing the number of FDA-approved menopausal hormone therapy prescriptions and are expected to grow…
In the Journals

Adiposity linked to better response to GH treatment in small for gestational age children

December 9, 2015
In short children born small for gestational age, higher body fat percentage appears to have a positive effect on growth hormone treatment response…
In the Journals

Progesterone therapy fails to prevent miscarriage

December 7, 2015
A significantly higher rate of live births among women with a history of miscarriages was not found with the use of progesterone supplements…
In the JournalsPerspective

Insulin sensitivity increases with testosterone therapy in men with type 2 diabetes

December 1, 2015
Testosterone treatment increased insulin sensitivity and lean body mass and decreased subcutaneous fat in men with type 2 diabetes and…
Cover StoryPublication Exclusive

Experts dispel myths surrounding early menopause and risks of hormone therapy

Endocrine Today, November 2015
Menopause typically brings with it a host of symptoms that can be unpleasant, at best, and at worst, can increase the risks for heart disease and…
In the Journals

Studies on psychosocial effects after GH treatment for short stature exhibit bias

November 23, 2015
Studies reporting on psychological outcomes after growth hormone treatment for short stature in children include a high risk for bias, in part due to…

Increase in juveniles seeking transgender HT spurs need for more research

November 20, 2015
The number of transgender juveniles and young adults seeking hormone therapy has increased sharply in recent years, according to a pair of physicians…
In the Journals

Acromegaly cardiomyopathy may be less prevalent than previously reported

October 29, 2015
In patients with active acromegaly, cardiomyopathy as assessed through cardiac MRI appears to be less common than once reported, according to recent…
In the Journals

Acromegaly cardiomyopathy may be less prevalent than previously reported

Endocrine Today, December 2015
In patients with active acromegaly, cardiomyopathy as assessed through cardiac MRI appears to be less common than once reported, according to recent…
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