Hormone Therapy

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Children with Silver-Russell syndrome gain height with growth hormone therapy

Children with Silver-Russell syndrome gain height with growth hormone therapy
April 21, 2016

Growth hormone therapy appears to yield height increases in children with Silver-Russell syndrome comparable to those gained by treated children without the disorder, according to recent findings.

In a prospective longitudinal study, Carolina C.J. Smeets, of the endocrinology division of the pediatrics department at Erasmus University Medical Center in Rotterdam, Netherlands, and colleagues evaluated 62 children with Silver-Russell syndrome (SRS) and 227 children without SRS born small for gestational age. Of the SRS group, 31 children had 11p15 aberrations and 11 had mUPD7 aberrations; 20 had idiopathic SRS. All patients were assigned GH 1 mg/m2 daily. Researchers recorded height, weight and Tanner stage three times a month.

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