Cardiometabolic Disorders

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One night of sleep loss may affect circadian genes, metabolic response

July 28, 2015

One night of sleep loss can alter “clock genes” in the body, potentially leading to metabolic effects, including insulin resistance, according to research in The Journal of Clinical Endocrinology & Metabolism.

In a randomized study involving young adult men who experienced both overnight wakefulness and sleep in a laboratory setting, researchers found that acute sleep deprivation increased promoter methylation and reduced the transcription of circadian genes in a tissue-specific manner, and was linked to an impaired glucose response.

James Floyd In the Journals

CV risk similar for second-line diabetes drugs plus metformin

July 27, 2015
Adults with type 2 diabetes using metformin combined with insulin have a similar cardiovascular risk when compared with adults using metformin combined with…
FDA NewsPerspective

FDA approves alirocumab for lowering of LDL in certain patients

July 24, 2015
The FDA and Sanofi/Regeneron announced that the agency has approved alirocumab, a PCSK9 inhibitor, for lowering of LDL in addition to diet and maximally tolerated statin…
Samar El Khoudary In the Journals

Heart fat volume related to menopausal status

July 20, 2015
Compared with premenopausal and early perimenopausal women regardless of age, obesity and other covariates, greater volumes of cardiovascular fat were found among late…
Obesity Consults

Obesity Consults: Volume 2, Number 5
Practical Guide to Medications Approved for Chronic Weight Management

Several pharmacologic options for the management of obesity have been approved by the US FDA, giving clinicians a range…
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Meeting News Coverage Video
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Lee M. Kaplan, MD, PhD: Individualized approach to obesity treatment most likely to succeed

October 27, 2014
BOSTON — In this video, Lee M. Kaplan, MD, PhD, director of the Obesity, Metabolism and Nutrition Institute at…
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CME
Obesity Consults: Volume 2, Number 4 Obesity and the Cardiovascular System

Obesity Consults: Volume 2, Number 4
Obesity and the Cardiovascular System

This activity is supported by an educational grant from Eisai, Inc. and Vivus, Inc.

Obesity is associated with a wide range of comorbid conditions, including diabetes, hypertension, sleep apnea, and…
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In the Journals

One night of sleep loss may affect circadian genes, metabolic response

July 28, 2015
One night of sleep loss can alter “clock genes” in the body, potentially leading to metabolic effects, including insulin resistance…
James Floyd In the Journals

CV risk similar for second-line diabetes drugs plus metformin

July 27, 2015
Adults with type 2 diabetes using metformin combined with insulin have a similar cardiovascular risk when compared with adults using metformin…
FDA NewsPerspective

FDA approves alirocumab for lowering of LDL in certain patients

July 24, 2015
The FDA and Sanofi/Regeneron announced that the agency has approved alirocumab, a PCSK9 inhibitor, for lowering of LDL in addition to diet and…
Samar El Khoudary In the Journals

Heart fat volume related to menopausal status

July 20, 2015
Compared with premenopausal and early perimenopausal women regardless of age, obesity and other covariates, greater volumes of cardiovascular fat…
In the Journals

Diabetes duration may predict CVD in Alström syndrome

July 16, 2015
Duration of diabetes appears to be predictive of aortic pulse wave velocity, which is subsequently associated with cardiovascular disease, in…
Bethany Brone Gibbs In the Journals

Sedentary time fails to predict metabolic parameters, outcome changes

July 15, 2015
Five-year changes in metabolic parameters or metabolic outcome incidence was not predicted by sedentary time, according to recent study findings…
In the Journals

Black adults without metabolic syndrome still at risk for vascular disease

July 10, 2015
Black adults without metabolic syndrome have worse vascular function when compared with whites, indicating that the consensus definition of the…
Renata D. Belfort De Aguiar In the Journals

Inhaled formoterol may lessen hypoglycemia in adults with type 1 diabetes

July 10, 2015
Inhalation of the long-acting selective beta 2-adrenergic receptor agonist formoterol can prevent or treat hypoglycemia in adults with type 1…
In the Journals

Liver resection safe for metabolic syndrome- and HCV-related HCC

July 9, 2015
Liver resection was safe among patients with metabolic syndrome- and hepatitis C virus-related hepatocellular carcinoma, with only cirrhosis…
In the Journals

Cardiometabolic multimorbidity reduces life expectancy

July 9, 2015
The risk for mortality is similar among patients with diabetes, stroke or MI, but a combination of these conditions was associated with a substantial…
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