Bone/Mineral Metabolism

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Higher osteoprotegerin levels associated with foot ulcer in type 1 diabetes

July 26, 2016

In patients with type 1 diabetes, higher levels of the glycoprotein osteoprotegerin are associated with development of a foot ulcer, independent of other well-known risk factors, according to recent findings.

“Diabetic foot ulcers are a frequent, disabling and costly occurrence; however, it is a complication often overlooked in terms of research,” Emilie Hein Zobel, MD, of the Steno Diabetes Center in Gentofte, Denmark, and colleagues wrote. “To the best of our knowledge, we are the first to show an association between higher levels of [osteoprotegerin] and development of foot ulcer in type 1 diabetes, independent of other risk factors. This might be attributed to the role of [osteoprotegerin] both in peripheral vascular disease and neuropathy; the two major factors contributing to foot ulcer.”

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Denosumab reduces cortical porosity in women with postmenopausal osteoporosis

July 25, 2016
Cortical porosity of the proximal femur shaft was reduced in women treated with denosumab therapy, study data show. The reduced cortical porosity results in increased…

Biologics application submitted for osteoporosis drug

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A Biologics License Application for romosozumab, an investigational monoclonal antibody much anticipated as a therapy for the treatment of osteoporosis in postmenopausal…
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AAP: Pediatricians need greater education to identify ‘female athlete triad’

July 21, 2016
Well-visit screening, educated diagnosis and combined intervention by pediatricians are suggested to effectively treat the female athlete triad in adolescents, according…
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In the Journals Plus

Higher osteoprotegerin levels associated with foot ulcer in type 1 diabetes

July 26, 2016
In patients with type 1 diabetes, higher levels of the glycoprotein osteoprotegerin are associated with development of a foot ulcer, independent of…

In the Journals Plus

Denosumab reduces cortical porosity in women with postmenopausal osteoporosis

July 25, 2016
Cortical porosity of the proximal femur shaft was reduced in women treated with denosumab therapy, study data show. The reduced cortical porosity…

Biologics application submitted for osteoporosis drug

July 23, 2016
A Biologics License Application for romosozumab, an investigational monoclonal antibody much anticipated as a therapy for the treatment of…

In the Journals

AAP: Pediatricians need greater education to identify ‘female athlete triad’

July 21, 2016
Well-visit screening, educated diagnosis and combined intervention by pediatricians are suggested to effectively treat the female athlete triad in…

In the Journals

BMD z scores similar in hypogonadotropic, hypergonadotropic hypogonadism

July 19, 2016
Adolescent girls with hypogonadotropic and hypergonadotropic hypogonadism had similar low bone mineral density z scores, which did not appear to be…

In the Journals

GH therapy increases fracture risk in patients previously treated for acromegaly

July 15, 2016
Adult patients with severe growth hormone deficiency previously treated for acromegaly saw an increased fracture risk after 6 years of growth hormone…

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No link found between vitamin D status, type 2 diabetes risk in older men

July 11, 2016
Serum 25-hydroxyvitamin D levels are not associated with incident type 2 diabetes in older men, according to an analysis of the Osteoporotic…

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Insulin resistance linked to favorable bone microarchitecture after menopause

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HT superior to oral contraceptives for increasing BMD in premature ovarian failure

June 28, 2016
In women with spontaneous premature ovarian failure, hormone therapy was shown to increase bone density at the lumbar spine at a greater rate vs…

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