July 26, 2016
In patients with type 1 diabetes, higher levels of the glycoprotein osteoprotegerin are associated with development of a foot ulcer, independent of other well-known risk factors, according to recent findings.
“Diabetic foot ulcers are a frequent, disabling and costly occurrence; however, it is a complication often overlooked in terms of research,” Emilie Hein Zobel, MD, of the Steno Diabetes Center in Gentofte, Denmark, and colleagues wrote. “To the best of our knowledge, we are the first to show an association between higher levels of [osteoprotegerin] and development of foot ulcer in type 1 diabetes, independent of other risk factors. This might be attributed to the role of [osteoprotegerin] both in peripheral vascular disease and neuropathy; the two major factors contributing to foot ulcer.”