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Advances in glucocorticoid therapy target congenital adrenal hyperplasia

March 2, 2015

HALIFAX, Nova Scotia — Novel formulations and delivery of steroids are producing better short-term outcomes for the treatment of congenital adrenal hyperplasia in clinical trials, according to a presenter here.

Adequate suppression of excess androgen requires cortisol replacement, but excessive replacement can result in adverse effects, such as obesity, short stature and lack of adequate growth in children, said Deborah Merke, MD, MS, a pediatric endocrinologist and senior investigator at the NIH Clinical Center in Bethesda, Maryland.

Exophthalmos and Cushing's Syndrome

February 3, 2015
A woman experienced red, irritated and bulging eyes. She saw an ophthalmologist who strongly suspected Graves’ ophthalmopathy. However, the patient did not have…
In the Journals

Vertebral fractures, cortisol secretion linked in postmenopausal women with type 2 diabetes

February 2, 2015
Vertebral fractures were associated with cortisol secretion and sensitivity in postmenopausal women with type 2 diabetes, according to research published in the Journal
FDA News

Congenital adrenal hyperplasia therapy granted orphan drug status

January 18, 2015
The FDA has granted orphan drug status to Neurocrine Biosciences, Inc., for NBI-77860, a proprietary corticotropin releasing factor 1 receptor antagonist for the…
CME
Obesity Consults: Volume 2, Number 2 Obesity Forum 2014 Highlights

Obesity Consults: Volume 2, Number 2
Obesity Forum 2014 Highlights

This activity is supported by educational grants from Takeda Pharmaceuticals International, Inc., US Region and Orexigen Therapeutics, Inc; Eisai, Inc.; Novo Nordisk; Vivus, Inc.

Management of obesity is complex, factoring in psychological, environmental, and physiologic causes. Treatment options…
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Obesity Consults: Volume 2, Number 3

Obesity Consults: Volume 2, Number 3
Biology and Behavior

This activity is supported by an educational grant from Vivus, Inc and Eisai Co., Ltd.

Obesity is a complex, multifactorial disease. Understanding how psychology, genetics, biology and neurobiology…
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Meeting News Coverage

Advances in glucocorticoid therapy target congenital adrenal hyperplasia

March 2, 2015
HALIFAX, Nova Scotia — Novel formulations and delivery of steroids are producing better short-term outcomes for the treatment of congenital…

Exophthalmos and Cushing's Syndrome

February 3, 2015
A woman experienced red, irritated and bulging eyes. She saw an ophthalmologist who strongly suspected Graves’ ophthalmopathy. However, the…
In the Journals

Vertebral fractures, cortisol secretion linked in postmenopausal women with type 2 diabetes

February 2, 2015
Vertebral fractures were associated with cortisol secretion and sensitivity in postmenopausal women with type 2 diabetes, according to research…
FDA News

Congenital adrenal hyperplasia therapy granted orphan drug status

January 18, 2015
The FDA has granted orphan drug status to Neurocrine Biosciences, Inc., for NBI-77860, a proprietary corticotropin releasing factor 1 receptor…
In the Journals

Cushing's syndrome subtype affects postoperative time to adrenal recovery

January 16, 2015
In patients undergoing curative surgical tumor resection for Cushing’s syndrome, the time to recovery of adrenal function is contingent upon…
J. Josh Snodgrass In the Journals

Cortisol level changes linked to intimate partner violence in women

December 30, 2014
Higher levels of physical victimization in women were linked to higher levels of cortisol in midday and less linear decline throughout the day…
In the Journals

Mild adrenal steroidogenic defects common in patients with high BP

December 26, 2014
Mild defects of adrenal steroidogenesis occur in nearly half of patients with high blood pressure, according to research published in the…

Neurocrine Biosciences launches trial for congenital adrenal hyperplasia therapy

December 21, 2014
After completing a pilot clinical trial in adults with classic congenital adrenal hyperplasia, Neurocrine Biosciences, Inc. announced a…
In the Journals

High rates of adrenal crisis seen in patients with chronic insufficiency

December 8, 2014
Adrenal crisis occurs in a large proportion of patients with chronic adrenal insufficiency, even if they are educated about managing the disease…
In the Journals

Need for hydrocortisone linked to negative disease perception among adrenal-insufficient patients

October 3, 2014
In patients with adrenal insufficiency, strong beliefs about the necessity of hydrocortisone replacement and concerns about its adverse effects are…
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