Adrenal

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Adrenal vein sampling, CT ‘imperfect’ tests to identify adrenalectomy candidates

June 22, 2016

In patients with primary aldosteronism, both adrenal CT scans and more-invasive adrenal vein sampling identified the presence of aldosterone-producing adenomas at similar rates and resulted in similar clinical benefits after 1 year of follow-up, but patients in both groups experienced unexpected surgical failures.

In a diagnostic, randomized controlled trial conducted at 13 Dutch and Polish medical centers, Tanja Dekkers, MD, of the division of vascular medicine at Radboud University Medical Center in Nijmegen, the Netherlands, and colleagues analyzed data from 184 adults with confirmed primary aldosteronism prescribed at least three antihypertensive drugs or with hypertension accompanied by spontaneous or diuretic-induced hypokalemia. Patients were recruited between July 2010 and May 2013. Researchers randomly assigned patients to undergo adrenal CT (n = 92) or adrenal vein sampling (AVS; n = 92). Patients assigned to CT underwent adrenalectomy in cases of a unilaterally enlarged adrenal with a normal contralateral gland; patients with bilaterally enlarged or normal adrenal glands were prescribed mineralocorticoid receptor antagonist therapy. Antihypertensive therapy was initiated and adjusted by treating physicians during follow-up to achieve target blood pressure. Primary outcome was the intensity of antihypertensive medication needed; secondary endpoints included serum potassium level and aldosterone after salt-loading test following adrenalectomy.

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Higher CV risk exists with prednisolone in adrenal insufficiency

June 3, 2016
Adults with adrenal insufficiency prescribed prednisolone therapy had higher levels of total and LDL cholesterol vs. patients prescribed hydrocortisone, according to…
Meeting News Coverage

Diagnostic PET/CT should be used with caution in high-risk adrenal cases

May 29, 2016
ORLANDO, Fla. — In patients at high-risk for adrenal malignancy, 18F-fluorodeoxyglucose-PET/CT imaging should be used with clinical judgment because of suboptimal…
In the Journals

C-peptide reliably predicts insulin secretion in children with GH deficiency

May 20, 2016
In children with growth hormone deficiency, C-peptide measurements provide a better estimate of insulin secretion than insulin levels throughout the first 12 months of…
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VIDEO: Late diagnosis of Cushing's disease still a problem

April 8, 2016
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Avoiding “Loss of Chance”…Improving the Screening, Treatment, and Referral of Patients with Diabetic Retinopathy

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In the Journals

Adrenal vein sampling, CT ‘imperfect’ tests to identify adrenalectomy candidates

June 22, 2016
In patients with primary aldosteronism, both adrenal CT scans and more-invasive adrenal vein sampling identified the presence of…

Meeting News Coverage

Higher CV risk exists with prednisolone in adrenal insufficiency

June 3, 2016
Adults with adrenal insufficiency prescribed prednisolone therapy had higher levels of total and LDL cholesterol vs. patients prescribed…

Meeting News Coverage

Diagnostic PET/CT should be used with caution in high-risk adrenal cases

May 29, 2016
ORLANDO, Fla. — In patients at high-risk for adrenal malignancy, 18F-fluorodeoxyglucose-PET/CT imaging should be used with clinical judgment…

In the Journals

C-peptide reliably predicts insulin secretion in children with GH deficiency

May 20, 2016
In children with growth hormone deficiency, C-peptide measurements provide a better estimate of insulin secretion than insulin levels throughout the…

In the Journals

Optimal CV health linked to sex steroids, SHBG in older adults

May 11, 2016
Women with lower levels of testosterone and free androgen index and higher levels of sex hormone-binding globulin and men with higher levels of sex…

Meeting News Coverage

Delayed diagnosis, barriers to care increase morbidity in children with Cushing’s syndrome

May 5, 2016
Hispanic and black children diagnosed with Cushing’s syndrome are more likely to present with higher cortisol measurements and larger tumor…

In the Journals

New diagnostic test quickly, accurately identifies primary aldosteronism

April 18, 2016
An overnight test for primary aldosteronism identified the condition in hypertensive adults with higher accuracy than a standard saline-loading test…

In the Journals

Higher FGF-23 levels found in residents of highly industrialized nations

April 18, 2016
Levels of fibroblast growth factor-23, which acts as a regulator of phosphate homeostasis, appear to be higher in residents of highly industrialized…

In the Journals

New guideline recommends 10-year follow-up for pheochromocytoma, paraganglioma

April 11, 2016
Patients who have undergone surgery to remove a pheochromocytoma or paraganglioma should be followed for at least 10 years to assess for local or…

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VIDEO: EDCs affect development across generations

April 8, 2016
BOSTON — In this video exclusive, Barbara A. Cohn, PhD, director of the Child Health and Development Studies at the Public Health Institute…

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