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Neurocrine Biosciences launches trial for congenital adrenal hyperplasia therapy

December 21, 2014

After completing a pilot clinical trial in adults with classic congenital adrenal hyperplasia, Neurocrine Biosciences, Inc. announced a trial for its proprietary corticotropin releasing factor 1 receptor antagonist in adolescents, according to a statement from the company.

The open-label, sequential cohort, single-ascending dose trial, known as the 1401 Study, for the drug NBI-77860 will involve approximately 15 adolescent girls with classic congenital adrenal hyperplasia (CAH), according to the statement.

In the Journals

High rates of adrenal crisis seen in patients with chronic insufficiency

December 8, 2014
Adrenal crisis occurs in a large proportion of patients with chronic adrenal insufficiency, even if they are educated about managing the disease, according to research…
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Neurocrine Biosciences launches trial for congenital adrenal hyperplasia therapy

December 21, 2014
After completing a pilot clinical trial in adults with classic congenital adrenal hyperplasia, Neurocrine Biosciences, Inc. announced a…
In the Journals

High rates of adrenal crisis seen in patients with chronic insufficiency

December 8, 2014
Adrenal crisis occurs in a large proportion of patients with chronic adrenal insufficiency, even if they are educated about managing the disease…
In the Journals

Need for hydrocortisone linked to negative disease perception among adrenal-insufficient patients

October 3, 2014
In patients with adrenal insufficiency, strong beliefs about the necessity of hydrocortisone replacement and concerns about its adverse effects are…

Lessons learned from AACE 2014

July 22, 2014
The need for a “hand-in-glove” integration of endocrinology and endocrine surgery was a key lesson learned at this year’s American…
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