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Urinary free cortisol measurement most accurate first-line test for Cushing's syndrome diagnosis

August 17, 2015

Measuring 24-hour urinary free cortisol with liquid chromatography-mass spectrometry is the most accurate first-line diagnostic tool for diagnosing Cushing’s syndrome in adults, according to research published in The Journal of Clinical Endocrinology & Metabolism.

Filippo Ceccato, MD, of the University Hospital of Padova, Italy, and colleagues analyzed data from 137 adults from 2012 to 2014 (108 women; mean age, 41 years) with clinical conditions suggestive of hypercortisolism. Within the cohort, 38 had a confirmed diagnosis of Cushing’s syndrome (27 women); 99 did not have the diagnosis. In all patients, researchers measured 24-hour urinary free cortisol with liquid chromatography-tandem mass spectrometry (LC-MS/MS), late-night salivary cortisol with a radio-immunometric method and serum cortisol with a 1-mg dexamethasone suppression test. Researchers performed all three tests on patients within 2 weeks to avoid fluctuations in cortisol production.

Lynette Nieman In the Journals

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In the Journals

Urinary free cortisol measurement most accurate first-line test for Cushing's syndrome diagnosis

August 17, 2015
Measuring 24-hour urinary free cortisol with liquid chromatography-mass spectrometry is the most accurate first-line diagnostic tool for diagnosing…
Lynette Nieman In the Journals

New guideline for Cushing’s syndrome recommends tumor removal

July 31, 2015
The Endocrine Society and the European Society for Endocrinology issued a new clinical practice guideline for managing Cushing’s syndrome…
FDA News

FDA grants breakthrough therapy designation to Azedra for pheochromocytoma, paraganglioma

July 28, 2015
The FDA granted breakthrough therapy designation to Ultratrace iobenguane I-131 for the treatment of patients with iobenguane-avid metastatic or…

Top 5 online adrenal stories from July

July 24, 2015
Endocrine Today has compiled a list of the top five adrenal stories posted in the last month.Healio.com/Endocrinology readers were interested in…
Karen K. Miller In the Journals

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