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Vitamin K antagonists do not affect bone mineral density, fracture risk

September 2, 2015

Vitamin K antagonists do not increase the risk for fracture or reduce bone mineral density, according to findings published in the Journal of Thrombosis and Haemostasis.

“Because osteocalcin, a protein produced by osteoblasts, undergoes the same carboxylation process [as vitamin K], the inhibition of the gamma-carboxylation exerted by vitamin K antagonists leads to lower incorporation in the bone matrix,” the researchers write. “Undercarboxylated osteolcalcin serum levels increase with the use of vitamin K antagonists, but whether this translates into fracture risk or lower bone mineral density values is still controversial.”

In the Journals

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In the Journals

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This activity is supported by an educational grant from Genentech, Inc.

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This activity is supported by an educational grant from Genentech, Inc.

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