An investigation of three biomarkers provided further clues to histogenesis and differentiation of syringoma, according to results presented at the American Academy of Dermatology Annual Meeting.
The researchers aimed to identify the cell that acts as the precise origin of a syringoma. They compared carcinoembryonic antigen, epithelial membrane antigen and cytokeratin 5 using the immunohistochemical staining in the solid strand of basophilic epithelial cells of syringoma.
The analysis involved 31 patients with biopsy-confirmed syringoma.
Samples were analyzed with antibodies to carcinoembryonic antigen, epithelial membrane antigen and cytokeratin 5.
The researchers commented on the markers, noting that carcinoembryonic antigen stains the luminal surface of sweat ductal structures; epithelial membrane antigen stains the peripheral cells of normal dermal ducts and the intraepidermal duct; and cytokeratin 5 stains the outer cells of the dermal duct and lower intraepidermal duct, but does not stain the intraepidermal duct located at the upper epidermis.
Results confirmed that the solid strands stained for epithelial membrane antigen and cytokeratin 5, as did the outer cells of the ductal structure. The solid strands did not stain with carcinoembryonic antigen, according to the findings.
“The results of the study indicate that the solid strands observed in syringomas originate from the outer cells of the two layers of cells that compose the lower epidermal duct, or the transitional portion between the intraepidermal duct and dermal duct in the normal eccrine or apocrine structure,” the researchers wrote. They concluded that a syringoma is developed by the proliferation of these cells.
For more information:
Kim KJ. #4731. An immunohistochemical study of the origin of the solid strand in syringoma, using carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), and cytokeratin (CK) 5. Presented at: The 70th Annual Meeting of the American Academy of Dermatology. March 16-20, 2012. San Diego, Calif.