Cardiology

Top Story

Apolipoprotein C-III inhibitor reduces triglycerides

July 30, 2015

Patients with hypertriglyceridemia treated with an antisense inhibitor of apolipoprotein C-III synthesis exhibited prolonged and dose-dependent reductions in triglycerides, according to results of a phase 2 study.

In the double blind, dose-ranging trial, researchers randomly assigned 85 patients with severe or uncontrolled hypertriglyceridemia to placebo or volanesorsen (Isis Pharmaceuticals), at a dose ranging from 100 mg to 300 mg once a week for 13 weeks. All patients also were receiving stable fibrate therapy and had baseline fasting triglyceride levels of 225 mg/dL to 2,000 mg/dL (mean, 376 mg/dL) or were not receiving any other treatment and had baseline fasting triglyceride levels of 350 mg/dL to 2,000 mg/dL (mean, 581 mg/dL).

In the Journals

Previously undiagnosed cardiovascular risk factors found in many patients with CRAO

July 30, 2015
A high percentage of patients with nonarteritic central retinal artery occlusion had pre-existing or newly diagnosed cardiovascular risk factors, according to a…
In the Journals

Anticoagulation appears safe, effective in patients with splanchnic vein thrombosis

July 30, 2015
Patients with splanchnic vein thrombosis have a substantial, long-term risk for other thrombotic events that can be further increased by underlying conditions, although…
In the Journals

High levels, gradual increases of sodium raise BP, hypertension risk

July 29, 2015
High and gradually increasing levels of dietary sodium intake were both associated with future BP increases and hypertension, according to the results of an…
In the Journals

Noninvasive test chosen in most cases of suspected CAD

July 29, 2015
Three out of four patients with new symptoms suggestive of CAD underwent noninvasive testing during their first examination, according to results of a real-world…
More News Headlines »
CME
Cardiology Case Consults

The Patient with Acute Coronary Syndrome

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of patients with acute coronary syndrome.
More »
Video
VIDEO: Joseph Rossano, MD, MS, discusses benefits of VADs for children with advanced HF

VIDEO: Joseph Rossano, MD, MS, discusses benefits of VADs for children with advanced HF

July 17, 2015
PHILADELPHIA — In this video, Joseph Rossano, MD, MS, FAAP, FAAC, medical director of HF/transplantation at…
More »
CME
Cardiology Case Consults

The Patient With Idiopathic Pulmonary Fibrosis

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of patients with idiopathic pulmonary fibrosis.
More »
morganatic-roan