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UNDER-ATP: Adenosine triphosphate-guided pulmonary vein isolation not effective

August 30, 2015

Read the Perspective from Christian Gerdes , MD, PhD

LONDON — In patients with atrial fibrillation undergoing catheter ablation, adenosine triphosphate-guided pulmonary vein isolation did not improve outcomes compared with standard pulmonary vein isolation, according to the results of the UNDER-ATP trial.

The findings are in contrast to those of the ADVICE trial, published in The Lancet in July, which found that adenosine-guided pulmonary vein isolation was associated with an increase in the rate of arrhythmia-free survival. The reason could be that the ADVICE trial was restricted to patients with paroxysmal AF, while the UNDER-ATP trial was open to patients with all types of AF, Atsushi Kobori, MD, from the division of cardiology at Kobe City General Medical Hospital, Kobe, Japan, said during a press conference at the European Society of Cardiology Congress 2015.

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