August 30, 2015
LONDON — Intravenous cyclosporine administered before PCI did not improve outcomes or prevent left ventricular remodeling at 1 year compared with placebo in patients with anterior STEMI.
The phase 3, randomized, double blind CIRCUS trial enrolled 970 patients with acute anterior STEMI and complete occlusion of the culprit coronary artery who were referred for PCI within 12 hours of symptom onset at 42 hospitals Belgium, France and Spain. Patients were randomly assigned to receive a bolus injection of cyclosporine (2.5 mg/kg body weight; CicloMulsion, NeuroVive Pharmaceutical) or placebo before coronary recanalization. Seven patients were lost between randomization and 1 year.