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Long-term paracetamol use may increase risk for adverse events

March 3, 2015

Researchers reported a dose-response association between paracetamol and adverse events similar to those observed with NSAIDs, including mortality, CV, gastrointestinal and renal adverse events, according to results of a systematic literature review.

“Although the studies we included contained somewhat imperfect data — as long-term observational studies usually do, with all sorts of biases that cannot be easily detected, such as use of over-the-counter medicines — people taking paracetamol long-term, especially at higher doses, were at risk for problems that are usually not thought of as side effects of paracetamol,” Philip Conaghan, PhD, FRACP, FRCP, professor of musculoskeletal medicine at the University of Leeds, told Cardiology Today.

Study: No benefit from anticoagulant use in Behçet’s disease

March 3, 2015
Patients with vascular manifestations of Behçet’s disease who received treatment with anticoagulants did not benefit from the therapy given in addition to…
In the Journals

Many with AF qualify for oral anticoagulation therapy under new guidelines

March 2, 2015
Most patients with atrial fibrillation not recommended for oral anticoagulation under previous guidelines are now eligible for therapy based on the newest guidelines…
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Data support predictive significance of superficial vein thrombosis

March 2, 2015
Researchers found that a history of superficial vein thrombosis may be predictive of venous and arterial thrombotic events and these findings may play an important role…
In the Journals

Pulmonary hypertension frequent comorbidity in patients with aortic stenosis undergoing TAVR

March 2, 2015
The presence of pulmonary hypertension may independently predict poor short- and long-term outcomes after transcatheter aortic valve replacement in patients with severe…
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