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PATHWAY-3: Amiloride-hydrochlorothiazide combination superior to either alone for uncontrolled hypertension

September 4, 2015

Read the Perspective from Steen Dalby Kristensen, MD, DMSc, FESC

LONDON — A combination of half doses of amiloride and hydrochlorothiazide was superior to full doses of either treatment alone in patients with uncontrolled hypertension, according to the results of the PATHWAY-3 trial.

Researchers hypothesized that adding amiloride, a potassium-sparing diuretic, to a thiazide diuretic would control BP and decrease diabetes risk in patients with uncontrolled hypertension (defined as systolic BP > 140 mm Hg) and at least one other component of the metabolic syndrome who were not previously taking a diuretic.

Marc S. Sabatine, MD, MPH FDA News

FDA approves ticagrelor for long-term use after ACS event

September 3, 2015
AstraZeneca announced that a 60 mg twice-daily dose of its antiplatelet agent ticagrelor has been approved by the FDA for prevention of CV death, MI and stroke in…
Meeting News Coverage

Early, sensitive troponin I assessment safe, effective for acute MI diagnosis

September 3, 2015
LONDON — A new algorithm incorporating a more sensitive cutoff for troponin I values to identify non-STEMI would result in lower mortality and allow more rapid…
Pamela S. Douglas, MD Meeting News CoveragePerspective

PLATFORM: FFR-CT reduces unnecessary invasive catheterization in patients with suspected CAD

September 3, 2015
LONDON — Patients with suspected CAD planned for invasive catheterization were less likely to undergo an unnecessary procedure if their diagnosis was guided by CTA…
VIDEO: Five IMPROVE-IT analyses indicate safety, efficacy of ezetimibe Meeting News CoverageVideo

VIDEO: Five IMPROVE-IT analyses indicate safety, efficacy of ezetimibe

September 3, 2015
LONDON — In this video, Robert P. Giugliano, MD, a cardiologist at Brigham and Women's Hospital and senior investigator with the TIMI Study Group, discusses…
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CME
Cardiology Case Consults

The Patient with Obesity

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of patients with obesity.
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Meeting News Coverage Video
VIDEO: ARTS-HF results indicate benefits of finerenone for certain patients with HF

VIDEO: ARTS-HF results indicate benefits of finerenone for certain patients with HF

September 2, 2015
LONDON — In this video, Richard A. Chazal, MD, FACC, medical director of the Heart and Vascular Institute at Lee…
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CME
Highlights from Lipid Forum 2015™: Focus on Hypertriglyceridemia

Highlights from Lipid Forum 2015®: Focus on Hypertriglyceridemia

This activity is supported by an educational grant from AstraZeneca.

Hypertriglyceridemia is a highly prevalent yet modifiable risk factor for atherosclerotic disease, pancreatitis, and…
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