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PATHWAY-3: Amiloride-hydrochlorothiazide combination superior to either alone for uncontrolled hypertension

September 4, 2015

Read the Perspective from Steen Dalby Kristensen, MD, DMSc, FESC

LONDON — A combination of half doses of amiloride and hydrochlorothiazide was superior to full doses of either treatment alone in patients with uncontrolled hypertension, according to the results of the PATHWAY-3 trial.

Researchers hypothesized that adding amiloride, a potassium-sparing diuretic, to a thiazide diuretic would control BP and decrease diabetes risk in patients with uncontrolled hypertension (defined as systolic BP > 140 mm Hg) and at least one other component of the metabolic syndrome who were not previously taking a diuretic.

Marc S. Sabatine, MD, MPH FDA News

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No commercial support for this activity.

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