Genetics/Genomics

Top Story

Personalized medicine may help patients with familial hypercholesterolemia

May 25, 2017

PHILADELPHIA — Genomics, proteomics and imaging may enable a personalized medicine strategy for patients with familial hypercholesterolemia, an expert said at the National Lipid Association Scientific Sessions.

Eric Sijbrands, MD, PhD, professor of internal medicine, head of the division of pharmacology, vascular and metabolic diseases and head of the Erasmus cardiovascular genetics department at Erasmus Medical Center in Rotterdam, the Netherlands, said a personalized medicine approach could work in the familial hypercholesterolemia (FH) population, but “prospective testing is needed to identify the FH mutation and calculate a genomic risk score to guide an individual treatment plan. We should monitor the treatment effect with peptides and check this with coronary CTA.”

Meeting News

Damaging mutations in ABCA1, APOA1 linked to atherosclerosis

May 19, 2017
PHILADELPHIA — In patients with low HDL, a damaging mutation in ABCA1 or APOA1 is associated with an increased risk for subclinical atherosclerosis compared with…
In the Journals

Blood test for patients with CAD symptoms may reduce unnecessary cardiac referrals

April 28, 2017
Patients with symptoms of obstructive CAD with a low score using a blood-based age/sex/gene expression test were less likely to be referred to a cardiologist, have…
In the JournalsPerspective

ANGPTL3 loss-of-function mutation may confer lower risk for CAD

April 17, 2017
Individuals with a deficiency of angiopoietin-like 3 had a decreased risk for CAD, even in the presence of risk factors, according to findings in the Journal of the
Meeting News

Personalized medicine may help patients with familial hypercholesterolemia

May 25, 2017
PHILADELPHIA — Genomics, proteomics and imaging may enable a personalized medicine strategy for patients with familial hypercholesterolemia, an…

Meeting News

Damaging mutations in ABCA1, APOA1 linked to atherosclerosis

May 19, 2017
PHILADELPHIA — In patients with low HDL, a damaging mutation in ABCA1 or APOA1 is associated with an increased risk for subclinical…

In the Journals

Blood test for patients with CAD symptoms may reduce unnecessary cardiac referrals

April 28, 2017
Patients with symptoms of obstructive CAD with a low score using a blood-based age/sex/gene expression test were less likely to be referred to a…

In the JournalsPerspective

ANGPTL3 loss-of-function mutation may confer lower risk for CAD

April 17, 2017
Individuals with a deficiency of angiopoietin-like 3 had a decreased risk for CAD, even in the presence of risk factors, according to findings in the…

Cardiology Today's top stories covered at the ACC Scientific Session

April 13, 2017
The American College of Cardiology Scientific Session featured important late- break ing clinical trials and other material presented by some of the…

In the Journals

Autoantibodies against GPIHBP1 protein found to cause hypertriglyceridemia

April 10, 2017
Researchers have determined a cause for severe hypertriglyceridemia and chylomicronemia. Stephen G. Young, MD, distinguished professor of…

Meeting NewsPerspective

GIFT: Genetics-based dosing improves warfarin safety

March 19, 2017
WASHINGTON — Pharmacogenetics-based warfarin dosing decreased adverse events compared with clinical-based dosing, investigators from the GIFT…

Meeting NewsPerspective

ORION-1: Inclisiran lowers LDL, PCSK9 in patients with hyperlipidemia, high CV risk

March 17, 2017
WASHINGTON — Inclisiran, a small interfering RNA that targets PCSK9 messenger RNA, was associated with reduced LDL and PCSK9 in the phase 2

Cover Story

Cardiologists play key role in helping patients mitigate high genetic CVD risk

Cardiology Today, March 2017
CVD is the leading cause of death in the United States, with about 610,000 related deaths each year, according to the CDC. Genetics play an important…

NIH issues grant for study of biological pacemakers

March 4, 2017
Cedars-Sinai Heart Institute researchers have received a $3 million grant from the NIH to develop a biological pacemaker that can treat patients with…

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