• CME
  • Statin Therapy: Assessing Intolerance, Drug Interactions and Use in Renal Insufficiency

  • Author(s)/Faculty: James A. Underberg, MD, MS, FACPM, FACP, FASH, FNLA; Dean A. Bramlet, MD; Alan S. Brown, MD, FACC, FNLA; Gregory S. Pokrywka, MD, FACP, FNLA, NCMP
    Source: Healio - Cardiology Today Education Lab
    Type: Multimedia Articles/Items: 7
    Release Date: 8/3/2012 Expiration Date: 8/2/2013
    Credit Type: CME Number of Credit(s): 2
    Cost: Free Provider: Vindico Medical Education
  • Dyslipidemia is a major modifiable risk factor for cardiovascular disease, especially in patients with type 2 diabetes and chronic kidney disease. Statins are a class of drugs effective in the treatment of dyslipidemia. They have been demonstrated to lower LDL-C, apolipoprotein B, and LDL-P levels. They have also been shown to raise HDL-C levels. However, statins have been associated with drug interactions and adverse effects such as fatigue, myalgias, myositis, myopathy, and increased risk for new onset diabetes. Physicians must be aware of how to effectively minimize the risk of these drug interactions and side effects through proper selection of a statin and strategies such as dose adjustment.

Sponsorship Statement: This continuing medical education activity is sponsored by Vindico Medical Education.

Support Statement: This activity is supported by an educational grant from .

Target Audience: The intended audience for this activity is internists and other healthcare professionals involved in the treatment of patients with dyslipidemia.

Learning Objectives: Upon successful completion of this activity, participants will be able to:

  1. Categorize the different pharmacokinetic profiles of approved statins to permit the selection of appropriate modalities that will not carry an increased risk of adverse events due to drug interactions.
  2. Describe the relative abilities of statins to modify both LDL-C and HDL-C and use evidence-based clinical study data, together with other parameters such as safety profiles, to optimize drug selection.
  3. Review the available safety data concerning statins, proteinuria, hyperglycemia, and dose reduction requirements in patients with kidney failure and apply this knowledge to therapeutic risk/benefit analysis.

Course Chair:
James A. Underberg, MD, MS, FACPM, FACP, FASH, FNLA
Clinical Assistant Professor of Medicine
NYU Medical School
Director, Bellevue Hospital Lipid Clinic
New York, NY

Faculty:
Dean A. Bramlet, MD
Medical Director
Cardiovascular Diagnostic Center
The Heart and Lipid Institute of Florida
St. Petersburg, FL
Assistant Consulting Professor of Medicine
Duke University
Durham, NC

Alan S. Brown, MD, FACC, FNLA
Interventional Cardiologist
Midwest Heart Specialists
Director, Midwest Heart Disease Prevention Center
Naperville, IL
Clinical Associate Professor of Medicine
Loyola Stritch School of Medicine
Loyola University Chicago
Chicago, IL

Gregory S. Pokrywka, MD, FACP, FNLA, NCMP
Director
Baltimore Lipid Center
Baltimore, MD

External Reviewer:
Carl E. Orringer, MD

Accreditation:
Vindico Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation:
Vindico Medical Education designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This enduring material is approved for 1 year from the date of original release, August 3, 2012 to August 2, 2013.

How To Participate in this Activity and Obtain CME Credit:
To participate in this CME activity, you must read the objectives, answer the pretest questions, read the articles, complete the CME posttest, and complete the evaluation. Provide only one (1) correct answer for each question. A satisfactory score is defined as answering 4 out of 5 of the posttest questions correctly. Upon receipt of the completed materials, if a satisfactory score on the posttest is achieved, Vindico Medical Education will issue an AMA PRA Category 1 Credit(s)™ certificate.

Disclosures:
In accordance with the Accreditation Council for Continuing Medical Education’s Standards for Commercial Support, all CME providers are required to disclose to the activity audience the relevant financial relationships of the planners, teachers, and authors involved in the development of CME content. An individual has a relevant financial relationship if he or she has a financial relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the CME activity content over which the individual has control.

The authors disclose that they do have significant financial interests in any products or class of products discussed directly or indirectly in this activity, including research support.

Planning Committee and Faculty members report the following relationship(s):
James A. Underberg, MD, MS, FACPM, FACP, FASH, FNLA
Consulting Fees: Genzyme, Liposcience
Fees for Non-CME Services: Abbott, Daiichi Sankyo, GSK, Forest, Merck, Kowa, Eli Lilly, Liposcience
Contracted Research: Kowa Research

Dean A. Bramlet, MD
Consulting Fees: Abbott, Kowa Lilly, Merck
Fees for Non-CME Services: Abbott, Kowa Lilly, Merck

Alan S. Brown, MD, FACC, FNLA
Fees for Non-CME Services: Abbott, Kowa

Gregory S. Pokrywka, MD, FACP, FNLA, NCMP
Fees for Non-CME Services: AstraZeneca, DSI, HDL, Kowa, Lilly, LipoScience, Metagenics

External Reviewer reports the following relationship(s):
Carl E. Orringer, MD
No relevant financial relationships to disclose.

Vindico Medical Education staff report the following relationship(s):
No relevant financial relationships to disclose.

Signed disclosures are on file at Vindico Medical Education, Office of Medical Affairs and Compliance.

Unlabeled and Investigational Usage:
The audience is advised that this continuing medical education activity may contain references to unlabeled uses of FDA-approved products or to products not approved by the FDA for use in the United States. The faculty members have been made aware of their obligation to disclose such usage. All activity participants will be informed if any speakers/authors intend to discuss either non-FDA approved or investigational use of products/devices.

Copyright Statement:
Created and published by Vindico Medical Education, 6900 Grove Road, Building 100, Thorofare, NJ 08086-9447. Telephone: 856-994-9400; Fax: 856-384-6680. Printed in the USA. Copyright © 2012 Vindico Medical Education. All rights reserved. No part of this publication may be reproduced without written permission from the publisher. The material presented at or in any of Vindico Medical Education continuing medical education activities does not necessarily reflect the views and opinions of Vindico Medical Education. Neither Vindico Medical Education nor the faculty endorse or recommend any techniques, commercial products, or manufacturers. The faculty/authors may discuss the use of materials and/or products that have not yet been approved by the US Food and Drug Administration. All readers and continuing education participants should verify all information before treating patients or utilizing any product.