February 21, 2017
Patients with type 2 diabetes and mild to moderate obesity who underwent Roux-en-Y gastric bypass or sleeve gastrectomy saw sustained improvements in HbA1c, body weight, lipid levels and quality of life 5 years after surgery that were superior to medical therapy alone, according to results from the STAMPEDE trial.
“Five years is a long time for follow-up, and that is one of the distinguishing features of this study,” Sangeeta Kashyap, MD, of the department of endocrinology, diabetes and metabolism at Cleveland Clinic, told Endocrine Today. “What is remarkable is patients who underwent bariatric surgery had far better glycemic control, with less use of insulin and medications. Almost 90% of patients did not need insulin after surgery. These patients had better triglycerides, higher HDL cholesterol levels, lower C-reactive protein levels, and maintained almost 20% total body weight loss. And, overall, based on their self-reported questionnaires, they had better quality of life.”