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Genetic variant reduces coronary events, increases diabetes risk in familial hypercholesterolemia

June 30, 2015

CHICAGO — A PCSK9 loss-of-function genetic variant was associated with a cardioprotective effect, but increased prevalence of diabetes and prediabetes in patients with familial hypercholesterolemia, according to results presented at the National Lipid Association Scientific Sessions.

Researchers performed genotyping in 724 patients with familial hypercholesterolemia and established the presence of the PCSK9 InsLEU genetic variant to determine its potential link to diabetes, glucose homeostasis and coronary events.

In the Journals

Preventable risk factors related to half of CV deaths in US adults

June 30, 2015
Preventable risk factors accounted for half of CV deaths in U.S. adults aged 45 to 79 years from 2009 to 2010, according to an analysis published in the Annals of
VIDEO: Expert discusses relationship between statin therapy, diabetes Meeting News CoverageVideo

VIDEO: Expert discusses relationship between statin therapy, diabetes

June 12, 2015
CHICAGO — Health care professionals should be aware of the link between statin use and increased risk for type 2 diabetes, especially among patients with risk…
Rury Holman Meeting News CoveragePerspective

No additional threat of heart failure with Januvia in high-risk adults with type 2 diabetes

June 8, 2015
BOSTON – The DPP-IV inhibitor Januvia does not increase cardiovascular risk or benefit in adults with type 2 diabetes at high risk for acute cardiovascular events…
CME
PCI in ACS: Deciding Among Clopidogrel, Prasugrel, or Ticagrelor

PCI in ACS: Deciding Among Clopidogrel, Prasugrel, or Ticagrelor

This activity is supported by an educational grant from Daiichi Sankyo, Inc. and Lilly USA, LLC

It is estimated that in the United States, each year, over 780,000 persons will experience an acute coronary syndrome…
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Meeting News Coverage Video
VIDEO: Best CV disease treatment approach for patients with diabetes still unclear

VIDEO: Best CV disease treatment approach for patients with diabetes still unclear

May 31, 2015
SAN DIEGO — Spencer King, III, MD, MACC, of the cardiology department at Emory Saint Joseph’s Hospital and…
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CME
Oral Antiplatelet Therapy in a Patient with Acute Coronary Syndrome and Percutaneous Coronary Intervention

Case Study: Oral Antiplatelet Therapy in a Patient with ACS and PCI

This activity is supported by an educational grant from Daiichi Sankyo, Inc. and Lilly USA, LLC

It is estimated that in the United States, over 780,000 persons annually will experience an acute coronary syndrome…
More »
Meeting News Coverage

Biguanides, liraglutide reduced CVD risk in type 2 diabetes

September 24, 2014
Patients with type 2 diabetes treated with biguanides and liraglutide have a reduced risk for ischemic heart disease, heart failure and stroke…
Stijn Peeters Meeting News Coverage

Higher plasma levels linked to CV complications in type 1 diabetes

September 18, 2014
Cardiovascular complications are associated with higher plasma levels in patients with type 1 diabetes, according to a presenter at the 50th European…
In the Journals

Age, diabetes duration increases risk for macrovascular complications

September 12, 2014
For patients with type 2 diabetes, macrovascular events and death are associated with age or age at diagnosis and diabetes duration, according to…
Matthew J. Price, MD In the Journals

Clopidogrel response impaired among patients with diabetes, CAD

September 4, 2014
Patients with diabetes and CAD experienced an impaired response to platelet P2Y12 receptor antagonist clopidogrel compared with those without…
In the Journals

Insulin use, dialysis predicted poor wound healing after endovascular therapy

August 28, 2014
Patients undergoing endovascular therapy for critical limb ischemia were significantly more likely to have non-healing wounds if they used insulin…
James F. McKinsey In the JournalsPerspective

DEFINITIVE LE published: Directional atherectomy effective regardless of diabetes status

August 27, 2014
Patients with or without diabetes who underwent directional atherectomy for peripheral artery disease experienced similar rates of primary patency at…

Nutrition education lacking in medical training

August 26, 2014
A group of physicians are questioning how well doctors can provide nutrition information and counseling to patients, particularly those with CVD…

AHA and ADA: CV risk assessment, monitoring essential for patients with type 1 diabetes

August 21, 2014
A greater understanding of the pathophysiology, risk prediction and treatment of CVD in patients with type 1 diabetes is essential to minimize the…
Steven E. Nissen, MD, MACC FDA News

FDA opens dialogue on interim results of CV safety in diabetes drug trials

August 12, 2014
The FDA has launched a dialogue on how to handle confidentiality of the interim results for cardiovascular outcomes in diabetes treatment trials…
In the Journals

Knowing modifiable risk factors may reduce CV death in type 2 diabetes

July 9, 2014
Determining vascular calcification and modifiable risk factors for heart disease could provide patients with type 2 diabetes the insight needed to…
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