Diabetes

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EXSCEL: Exenatide meets primary safety objective for CV risk in type 2 diabetes

May 23, 2017

Top-line results from the EXSEL trial show the GLP-1 receptor agonist exenatide extended release met the primary safety objective of non-inferiority for major adverse cardiac events in patients with type 2 diabetes when compared with placebo, Astra Zeneca announced in a press release.

The Exenatide Study of Cardiovascular Event Lowering trial compared the effect of once-weekly exenatide extended release (Bydureon) added to usual care with placebo on the risk for the composite endpoint of CV death, non-fatal myocardial infarction or non-fatal stroke, in adults with type-2 diabetes at a wide range of CV risk. The EXSCEL trial is the largest and most inclusive patient population of any CV outcomes trial of the GLP-1 receptor agonist class conducted to date, including more than 14,000 patients from 35 countries, according to the release.

Meeting News

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Meeting News

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In the Journals

Low socioeconomic status as significant a risk factor for mortality as diabetes, high blood pressure, obesity

February 17, 2017
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In the Journals Plus

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February 16, 2017
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In the Journals Plus

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February 15, 2017
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In the Journals Plus

Dapagliflozin improves glycemic control, weight, BP in patients with type 2 diabetes, HF

February 15, 2017
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In the Journals

Higher SYNTAX score may predict benefit from CABG vs. medical therapy

February 6, 2017
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In the Journals Plus

Fish consumption associated with lower MI incidence in type 2 diabetes

February 1, 2017
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In the Journals

Stroke risk higher with AF, insulin-requiring diabetes vs. without insulin

January 31, 2017
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In the Journals Plus

Similar stroke risk in adults with type 2 diabetes, healthy BP vs. general population

January 27, 2017
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In the Journals Plus

Low vitamin D level predicts CV morbidity, mortality in type 2 diabetes

January 25, 2017
Older adults with type 2 diabetes and low 25-hydroxyvitamin D levels were more likely to experience a cardiovascular event vs. those with higher…

In the Journals

Diabetes management among Latino patients begins with language-concordant care

January 23, 2017
Although glycemic control improved among Latino diabetes patients with limited English proficiency when treated by Spanish-speaking primary care

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