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EXSCEL: Exenatide meets primary safety objective for CV risk in type 2 diabetes

May 23, 2017

Top-line results from the EXSEL trial show the GLP-1 receptor agonist exenatide extended release met the primary safety objective of non-inferiority for major adverse cardiac events in patients with type 2 diabetes when compared with placebo, Astra Zeneca announced in a press release.

The Exenatide Study of Cardiovascular Event Lowering trial compared the effect of once-weekly exenatide extended release (Bydureon) added to usual care with placebo on the risk for the composite endpoint of CV death, non-fatal myocardial infarction or non-fatal stroke, in adults with type-2 diabetes at a wide range of CV risk. The EXSCEL trial is the largest and most inclusive patient population of any CV outcomes trial of the GLP-1 receptor agonist class conducted to date, including more than 14,000 patients from 35 countries, according to the release.

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