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Genetic variant reduces coronary events, increases diabetes risk in familial hypercholesterolemia

June 30, 2015

CHICAGO — A PCSK9 loss-of-function genetic variant was associated with a cardioprotective effect, but increased prevalence of diabetes and prediabetes in patients with familial hypercholesterolemia, according to results presented at the National Lipid Association Scientific Sessions.

Researchers performed genotyping in 724 patients with familial hypercholesterolemia and established the presence of the PCSK9 InsLEU genetic variant to determine its potential link to diabetes, glucose homeostasis and coronary events.

In the Journals

Preventable risk factors related to half of CV deaths in US adults

June 30, 2015
Preventable risk factors accounted for half of CV deaths in U.S. adults aged 45 to 79 years from 2009 to 2010, according to an analysis published in the Annals of
VIDEO: Expert discusses relationship between statin therapy, diabetes Meeting News CoverageVideo

VIDEO: Expert discusses relationship between statin therapy, diabetes

June 12, 2015
CHICAGO — Health care professionals should be aware of the link between statin use and increased risk for type 2 diabetes, especially among patients with risk…
Rury Holman Meeting News CoveragePerspective

No additional threat of heart failure with Januvia in high-risk adults with type 2 diabetes

June 8, 2015
BOSTON – The DPP-IV inhibitor Januvia does not increase cardiovascular risk or benefit in adults with type 2 diabetes at high risk for acute cardiovascular events…
CME
Cardiology Case Consults

The Patient with Acute Coronary Syndrome

No commercial support for this activity.

This CME activity will focus on the diagnosis and management of patients with acute coronary syndrome.
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Meeting News Coverage Video
VIDEO: Best CV disease treatment approach for patients with diabetes still unclear

VIDEO: Best CV disease treatment approach for patients with diabetes still unclear

May 31, 2015
SAN DIEGO — Spencer King, III, MD, MACC, of the cardiology department at Emory Saint Joseph’s Hospital and…
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CME
PCI in ACS: Deciding Among Clopidogrel, Prasugrel, or Ticagrelor

PCI in ACS: Deciding Among Clopidogrel, Prasugrel, or Ticagrelor

This activity is supported by an educational grant from Daiichi Sankyo, Inc. and Lilly USA, LLC

It is estimated that in the United States, each year, over 780,000 persons will experience an acute coronary syndrome…
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In the Journals

Type 1 diabetes increases post-CABG mortality risk

April 22, 2015
Patients with type 1 diabetes appear to have twice the risk for death after undergoing CABG than patients without type 1 diabetes, according to…
FDA News

FDA panel recommends label changes for Nesina

April 16, 2015
An FDA advisory panel recommended label changes for the diabetes drug Nesina after results from a cardiovascular outcomes trial revealed an increased…
FDA News

FDA panel recommends new safety labeling for Onglyza

April 15, 2015
An FDA advisory panel recommended label changes for the diabetes drug Onglyza after results from a cardiovascular outcomes trial revealed an…
Meeting News Coverage

Glycemic control may improve clopidogrel response in patients with stable CAD

April 10, 2015
SAN DIEGO — In patients with stable CAD, high levels of plasma glucose reduced clopidogrel efficacy, according to data presented at the…
In the Journals

CABG may confer improved survival over PCI in patients with diabetes

April 8, 2015
Among patients with diabetes with CVD in the Coronary Artery Revascularization Evaluation registry, CABG was associated with better long-term…
In the Journals

Diabetes risk higher for middle-aged adults who habitually stay up late

April 1, 2015
Diabetes, metabolic syndrome and sarcopenia were more likely to develop in people who prefer late nights than in early risers, even with the same…
In the Journals

Higher CV risk with acarbose than metformin in type 2 diabetes

March 27, 2015
In the nationwide cohort study, Lee-Ming Chuang, MD, PhD, of Nationwide Taiwan University Hospital, and colleagues evaluated data from the Taiwan…
In the Journals

Updated diabetes care guidelines for PCPs stress importance of individualized treatment

March 23, 2015
Recent updates to the American Diabetes Association’s Standards of Medical Care in Diabetes place an emphasis on individualizing and tailoring…
In the Journals

Diabetes prevalence lower in patients with familial hypercholesterolemia than unaffected relatives

March 11, 2015
Patients with familial hypercholesterolemia had a lower prevalence of type 2 diabetes compared with relatives without familial hypercholesterolemia…
Gabriela Vazquez-Benitez In the Journals

Diabetes, CVD increase rates of CV events

February 27, 2015
Among adults with diabetes, paying extra attention to traditional cardiovascular risk factors could reduce the rates of cardiovascular events and…
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