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WOSCOPS: 20-year follow-up demonstrates clinical benefit of statins in men

November 26, 2014

CHICAGO — At 20 years, men assigned statin therapy during the 5-year West of Scotland Coronary Prevention Study had lower rates for mortality and CV events compared with men assigned placebo, regardless of whether they continued taking statins, according to findings presented at the American Heart Association Scientific Sessions.

From 1989 to 1995, researchers randomly assigned 6,595 men aged 45 to 64 years to pravastatin 40 mg/day or placebo. For the original West of Scotland Coronary Prevention Study (WOSCOPS), they remained randomly assigned for 5 years. After the initial 5-year period, in which the pravastatin group had LDL lowered by approximately 20% more than the placebo group, participants continued to be followed, but their general practitioners decided whether to initiate or continue statin therapy. An interim analysis had found that after the original trial, statin usage was equal in both treatment arms, with 31% of men in both groups using statins.

Jeff Volek In the Journals

Metabolic syndrome risk markers influenced by dietary carbohydrates

November 25, 2014
Dietary fat does not drive up plasma saturated fat in patients with obesity or overweight who have metabolic syndrome, according to research published in PLOS
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Anna Axelsson, MD: Results from INHERIT do not 'close the door' on losartan

November 24, 2014
CHICAGO — While results from the INHERIT trial indicate that losartan had no effect on left ventricular mass or other clinical endpoints compared with placebo in…
In the Journals

CDC: Overall heart disease death rate fell, increased in certain subtypes

November 21, 2014
In a letter published in JAMA, researchers from the CDC reported that mortality rates for heart disease overall have declined, but increases were seen in certain…
CME
Risk Management in the Cardiovascular Disease Arena

Risk Management in the Cardiovascular Disease Arena: Focus on Glycemic Control

This activity is supported by an educational grant from Genentech.

Among the multiple comorbidities and complications that are associated with type 2 diabetes mellitus (T2DM)…
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Meeting News Coverage Video
Healio AHA2014 Underberg th

IMPROVE-IT results provide long-awaited answers

November 17, 2014
CHICAGO – In this video, James A. Underberg, MD, discusses the highly anticipated results of IMPROVE-IT, a trial…
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CME
Practical Lipidology

Practical Lipidology: 2013

This activity is supported by an educational grant from Genentech.

The rise in the prevalence of obesity in the last few decades and its growing impact on health has driven the…
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Meeting News Coverage

WOSCOPS: 20-year follow-up demonstrates clinical benefit of statins in men

November 26, 2014
CHICAGO — At 20 years, men assigned statin therapy during the 5-year West of Scotland Coronary Prevention Study had lower rates for mortality…
Jeff Volek In the Journals

Metabolic syndrome risk markers influenced by dietary carbohydrates

November 25, 2014
Dietary fat does not drive up plasma saturated fat in patients with obesity or overweight who have metabolic syndrome, according to research…
thumbnail for video 3907832195001 Meeting News CoverageVideo

Anna Axelsson, MD: Results from INHERIT do not 'close the door' on losartan

November 24, 2014
CHICAGO — While results from the INHERIT trial indicate that losartan had no effect on left ventricular mass or other clinical endpoints…
In the Journals

CDC: Overall heart disease death rate fell, increased in certain subtypes

November 21, 2014
In a letter published in JAMA, researchers from the CDC reported that mortality rates for heart disease overall have declined, but increases were…
Marcus Lind In the JournalsPerspective

Patients with type 1 diabetes at increased risk for all-cause, CVD mortality

November 20, 2014
The likelihood of dying from any cause or CV causes is two times higher in patients with type 1 diabetes and an HbA1c level ≤6.9% compared with…
Varun Kumar, MD Meeting News Coverage

Cocaine use associated with coronary microvascular dysfunction

November 19, 2014
CHICAGO — New data suggest that cocaine users with chest pain may have coronary microvascular dysfunction, despite the absence of significant…
Anand K. Rohatgi, MD Meeting News Coverage

Cholesterol efflux capacity inversely associated with CV events

November 19, 2014
CHICAGO — Cholesterol efflux capacity, a biomarker of reverse cholesterol transport, was inversely associated with CV events in participants of…
Parag Joshi Meeting News CoverageBlog

Late-breaking clinical trials in CVD prevention: Where are the events?

November 18, 2014
by Parag H. Joshi, MD, MHS CHICAGO — The cold weather in Chicago seems to have led to increased attendance at talks, if for nothing else than…
Meeting News CoveragePerspective

INHERIT: Losartan did not improve left ventricular mass in patients with hypertrophic cardiomyopathy

November 18, 2014
CHICAGO — Use of losartan in patients with overt hypertrophic cardiomyopathy had no effect on left ventricular mass or endpoints such as…
Mikhail N. Kosiborod, MD Meeting News Coverage

HARMONIZE: ZS-9 reduced serum potassium in patients with hyperkalemia

November 18, 2014
CHICAGO — Treatment with sodium zirconium cyclosilicate was associated with rapid and sustained reductions in serum potassium compared with…
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